Characteristic of glucose uptake in rat skeletal muscle after hypoxia acclimatization
Characteristic of glucose uptake in rat skeletal muscle after hypoxia acclimatization
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发表时间：
2004
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通讯作者：
Gao Yu
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作者：
Gao Yu
目的探讨低氧习服后组织葡萄糖转运的特点。方法Wistar大鼠模拟海拔5 000 m低压缺氧30 d后，测定血气、血糖、血常规，并测定骨骼肌葡萄糖水平、葡萄糖摄取率、葡萄糖转运蛋白结合位点和亲和力。比较低氧组与对照组（海平面组）的各项指标。结果低氧组血糖水平明显高于对照组（P 0 0 5）。低氧习服组大鼠骨骼肌葡萄糖水平、葡萄糖摄取率、葡萄糖结合位点数均显著高于海平面组。结论低氧习服后葡萄糖摄取能力增强可能是低氧暴露时优先利用葡萄糖的机制之一。
Objective To investigate the characteristic of glucose transport in tissue after hypoxia acclimatization. Methods After Wistar rats were exposed to hypobaric hypoxia simulating an altitude of 5 000 m for 30 d, determination of the blood gas, blood sugar and routine blood examination were conducted; the glucose level, the glucose uptake rate, the binding sites, and the affinity of glucose transporters in skeletal muscle were also determined. Indices in the hypoxic group were compared with those in the control group (sea level group). Results The blood sugar level in the hypoxic group was significantly higher than that in the control group ( P 0 05). The glucose level, the uptake rate, and the number of binding sites in skeletal muscle after hypoxia acclimatization were also significantly higher than those in sea level group. Conclusion The enhanced ability of glucose uptake after hypoxia acclimatization may be one of the mechanisms of utilizing glucose preferentially during hypoxic exposure.