How cells build totipotency and pluripotency: nuclear, chromatin and transcriptional architecture.
How cells build totipotency and pluripotency: nuclear, chromatin and transcriptional architecture.
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DOI：
10.1016/j.ceb.2015.04.006
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发表时间：
2015-06
影响因子：
7.5
通讯作者：
T. Dang-Nguyen;M. Torres-Padilla
中科院分区：
文献类型：
--
作者：
T. Dang-Nguyen;M. Torres-Padilla
Totipotent and pluripotent cells display different degrees of cellular plasticity. After fertilization, embryonic cells transit naturally from a totipotent to a pluripotent state. Major changes in nuclear architecture, chromatin mobility and gene expression occur during this transition. In particular, nuclear architecture has recently emerged as a potential regulator of heterochromatin formation in the early embryo. Future research should address whether a causal, functional link between nuclear organization and gene regulation is a general theme during reprogramming and the formation of pluripotent cells.
