Nucleosome positioning: multiple mechanisms toward a unifying goal.

Nucleosome positioning: multiple mechanisms toward a unifying goal.
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核小体定位:实现统一目标的多种机制。

DOI:
10.1016/j.molcel.2012.09.015
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发表时间:
2012
期刊:
影响因子:
16
通讯作者:
Workman,JerryL
Workman,JerryL
中科院分区:
生物学1区
文献类型:
--
作者:
Dutta,Arnob;Workman,JerryL

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在本期中,Hughes等人。(2012)的研究表明,核小体定位不是由任何单一机制决定的,而是由多种因素的协调作用决定的,包括潜在的DNA序列、物种特有的DNA结合蛋白、染色质重构体和转录机制。
In this issue, Hughes et al. (2012) show that nucleosome positioning is determined not by any single mechanism, but by the coordinated action of multiple factors, including the underlying DNA sequence, species-specific DNA binding proteins, chromatin remodelers, and the transcription machinery.