Pulse Wave Velocity and Flow in the Carotid Artery Versus the Aortic Arch: Effects of Aging
Pulse Wave Velocity and Flow in the Carotid Artery Versus the Aortic Arch: Effects of Aging
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DOI：
10.1002/jmri.24470
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发表时间：
2014-08-01
影响因子：
4.4
通讯作者：
Westenberg, Jos J. M.
中科院分区：
文献类型：
--
作者：
Kroner, Eleanore S. J.;Lamb, Hildo J.;Westenberg, Jos J. M.
目的：探讨脉搏波速度(PWV)评价动脉和颈动脉僵硬度的差异，利用速度编码磁共振成像(MRI)评价动脉血流量的分布，以及年龄对动脉和颈动脉PWV耦合性的影响。材料和方法：16名成年年轻志愿者(年龄45岁)接受3T MRI检查，用传递时间法测量主动脉和颈动脉的血流量和PWV。结果：年轻志愿者的动脉和颈动脉PWV比率为1.2，老年志愿者为0.95，显示血管壁僵硬的水平。此外，老年受试者颈内动脉每分钟血流量低于年轻受试者(平均血流量为177±/-42mL/min/m(2)比147±/-32mL/min/m(2)，P=0.028)，而主动脉和颈总动脉血流量无差异。因此，与年轻志愿者相比，老年志愿者流向脑的血流量比例较小(61+/-9%比71+/-8%，P=0.002)。结论：老年人主动脉和颈动脉之间的脉搏血流量水平与流向脑的血流量减少有关。速度编码MRI可用于评估主动脉弓和颈动脉循环的PWV和血流量分布。
Purpose: To explore differences in arterial stiffness of the aorta and carotid artery, assessed by pulse wave velocity (PWV), to evaluate the blood flow volume distribution towards the carotid circulation and to assess the effect of aging on the coupling between aortic and carotid PWV using velocity-encoded magnetic resonance imaging (MRI).Materials and Methods: Sixteen adult younger volunteers (age 45 years) underwent 3T MRI examination to assess aortic and carotid flow volumes and PWV using the transit time method.Results: Aortic versus carotid PWV-ratio was 1.2 for younger volunteers and 0.95 for older volunteers, demonstrating leveling of wall stiffness. Furthermore, flow volume per minute in the internal carotid artery was lower for older versus younger volunteers (mean volume 177 +/- 42 mL/min/m(2) vs. 147 +/- 32 mL/min/m(2), P = 0.028), whereas aorta and common carotid artery flow volumes were not different. Consequently, the fraction of blood flow volume towards the brain was smaller for older versus younger volunteers (61 +/- 9% versus 71 +/- 8%, P = 0.002).Conclusion: PWV-leveling between aorta and carotid artery at older age is associated with a reduction in blood flow volume towards the brain. Velocity-encoded MRI can be used to evaluate PWV and flow volume distribution in the aortic arch and the carotid circulation.