The epidemiology of prolactinomas.
The epidemiology of prolactinomas.
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DOI：
10.1007/s11102-005-5079-0
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发表时间：
2005-01-01
期刊：
影响因子：
3.8
通讯作者：
Beckers, Albert
中科院分区：
文献类型：
--
作者：
Ciccarelli, Antonio;Daly, Adrian F;Beckers, Albert
催乳素分泌瘤（催乳素瘤）是最常见的垂体瘤，其发生率随年龄和性别而变化。它们最常发生在20至50岁的女性中，此时女性与男性的比例约为10：1。在儿童-青少年年龄组中，泌乳素瘤的患病率为100/百万人口，占所有颅内肿瘤的不到2%。催乳素瘤发生在大约30%的多发性内分泌腺瘤病1型患者中，在这种情况下，它们可能比散发的同类更具侵袭性。Carney综合征或McCune-Albright综合征的患者可能会出现高催乳素血症，这是由于垂体瘤来源于分泌生长激素和催乳素的促生长催乳细胞。在文献中，很少有与MEN-1无关的泌乳素瘤家族病例报告。
Prolactin-secreting tumors (prolactinomas), the most frequently occurring pituitary tumor, have a frequency that varies with age and sex. They occur most frequently in females aged 20 to 50 years old, at which time the female-to-male ratio is approximately 10:1. In the pediatric-adolescent age group, prolactinomas have a prevalence of 100/million population, and account for less than 2% of all intracranial tumors. Prolactinomas occur in approximately 30% of patients with multiple endocrine neoplasia type 1 and in this setting, they may be more aggressive than their sporadic counterparts. Patients with Carney complex or McCune-Albright syndrome may exhibit hyperprolactinemia due to a pituitary tumor derived from somatomammotropic cells that secrete both growth hormone and prolactin. Few familial cases of prolactinoma unrelated to MEN-1 are reported in literature.