Human striatal activation during adjustment of the response criterion in visual word recognition
Human striatal activation during adjustment of the response criterion in visual word recognition
复制标题
DOI：
10.1016/j.neuroimage.2010.08.062
复制
发表时间：
2011-02-01
期刊：
影响因子：
5.7
通讯作者：
Herrmann, Manfred
中科院分区：
文献类型：
--
作者：
Kuchinke, Lars;Hofmann, Markus J.;Herrmann, Manfred
最近的计算模型研究结果表明，纹状体在人类认知中的一般功能与选择过程中的决策标准有关。我们使用功能性磁共振成像（fMRI）在21名健康受试者检查的血流动力学反应时，受试者改变他们的反应标准，在一个试验的基础上，词汇决策范式。当受试者在单词试验后的试验中比在非单词试验后的试验中反应更快时，可以获得逐个试验的标准设置-无论当前试验的词汇性如何。由于在当前试验中选择要求同样高，我们期望观察与反应标准转变相关的神经激活。的行为数据显示，更快的反应，在试验中的文字试验相比，试验非文字试验的顺序效应，这表明受试者改变他们的反应标准的试验的基础上。神经反应显示，只有在单词试验之后的试验中，纹状体中的信号才增加。因此，这种纹状体激活可能与反应标准设置有关。它表明了纹状体在视觉单词识别中改变决策标准的作用，这不能归因于纯粹的错误相关处理或首选反应的选择。(C)2010年爱思唯尔公司All rights reserved.
Results of recent computational modelling studies suggest that a general function of the striatum in human cognition is related to shifting decision criteria in selection processes. We used functional magnetic resonance imaging (fMRI) in 21 healthy subjects to examine the hemodynamic responses when subjects shift their response criterion on a trial-by-trial basis in the lexical decision paradigm. Trial-by-trial criterion setting is obtained when subjects respond faster in trials following a word trial than in trials following nonword trials - irrespective of the lexicality of the current trial. Since selection demands are equally high in the current trials, we expected to observe neural activations that are related to response criterion shifting. The behavioural data show sequential effects with faster responses in trials following word trials compared to trials following nonword trials, suggesting that subjects shifted their response criterion on a trial-by-trial basis. The neural responses revealed a signal increase in the striatum only in trials following word trials. This striatal activation is therefore likely to be related to response criterion setting. It demonstrates a role of the striatum in shifting decision criteria in visual word recognition, which cannot be attributed to pure error-related processing or the selection of a preferred response. (C) 2010 Elsevier Inc. All rights reserved.