Candida auris Biofilm Colonization on Skin Niche Conditions.
Candida auris Biofilm Colonization on Skin Niche Conditions.
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耳念珠菌生物膜在皮肤环境中的定植。
DOI：
10.1128/msphere.00972-19
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发表时间：
2020
期刊：
影响因子：
4.8
通讯作者：
Uppuluri,Priya
中科院分区：
文献类型：
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作者：
Uppuluri,Priya
金黄色念珠菌是一种新出现的多重耐药酵母菌，最近与世界各地卫生保健机构侵袭性感染的爆发有关。它作为一种医院病原体的成功在于它能够在重症监护病房(ICU)长期维持，熟练地在皮肤上定植，并在患者中传播。人们对金黄色葡萄球菌偏爱皮肤的机制或其在皮肤上的弹性程度知之甚少。现在，M.V.Horton，C.J.Johnson，J.F.Kernien，T.D.Patel等人。(mSphere5：e00910-19,2020，https://doi.org/10.1128/mSphere.00910-19)证明，在模拟腋下皮肤条件的合成汗液中，金黄色葡萄球菌可以生长成多层细胞，称为生物膜，可以抵抗干燥。利用一种新颖的活体动物皮肤定植模型，进一步阐述了C.Auris形成生物膜的倾向。这些研究提供了早期证据，表明持续存在于皮肤上的金黄色葡萄球菌生物膜细胞可能是卫生保健机构持续爆发的来源。阻止皮肤上金黄色葡萄球菌生物膜生长的干预措施将有助于控制这种病原体的传播。
Candida auris, an emerging multidrug-resistant yeast, has recently been associated with outbreaks of invasive infections in health care facilities worldwide. Its success as a nosocomial pathogen lies in its capability to sustain for prolonged periods in the intensive care unit (ICU), adeptly colonize skin, and spread among patients. Little is known of the mechanism behind the predilection of C. auris for skin or the extent of its resilience on it. Now, M. V. Horton, C. J. Johnson, J. F. Kernien, T. D. Patel, et al. (mSphere 5:e00910-19, 2020, https://doi.org/10.1128/mSphere.00910-19) demonstrate that in synthetic sweat medium designed to mimic axillary skin conditions, C. auris can grow into multilayers of cells called biofilms that can resist desiccation. C. auris’ propensity to form biofilms was further elaborated using a novelex vivoporcine skin model of skin colonization. These studies provide early evidence that C. auris biofilm cells persisting on skin could serve as source of continuing outbreaks in health care facilities. Interventions blocking C. auris biofilm growth on skin will help control the spread of this pathogen.