Differential effects of furosemide on porcine bronchial arterial and airway smooth muscle.
Differential effects of furosemide on porcine bronchial arterial and airway smooth muscle.
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呋塞米对猪支气管动脉和气道平滑肌的差异作用。
DOI：
10.1152/jappl.2000.89.4.1360
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Taylor,AE
中科院分区：
文献类型：
--
作者：
Corboz,MR;Ballard,ST;Gao,H;Benoit,JN;Inglis,SK;Taylor,AE
速尿作为气溶胶预处理可减轻哮喘患者的气道阻塞。速尿的这种保护作用可能与支气管平滑肌松弛或支气管血流量增加有关。为了确定速尿是否扩张支气管平滑肌，研究了幼猪远端支气管的等长收缩反应。在10−5M乙酰胆碱预收缩的支气管平滑肌环中，10−8 ~ 3 × 10−6M异丙肾上腺素出现明显的松弛，而10−8 ~ 10−3M呋塞米则没有。相比之下，预收缩支气管动脉用10−4M去甲肾上腺素或10−8M抗利尿素分别对10−4 ~ 3 × 10−3M和10−3 ~ 3 × 10−3M呋塞米有明显放松反应。我们得出结论，在上述实验条件下，速尿能松弛气道血管平滑肌，但不能松弛支气管平滑肌。这些结果与先前的建议一致，即吸入速尿增加气道组织的血流量（Gilbert IA, Lenner KA, Nelson JA， Wolin AD和Fouke JM）。中国生物医学工程学报（英文版）。
Furosemide attenuates airway obstruction in asthmatic subjects when administered as an aerosol pretreatment. This protective effect of furosemide could be related to relaxation of bronchial smooth muscle or to increased bronchial blood flow. To determine whether furosemide dilates bronchial smooth muscle, isometric contractile responses in distal bronchi from young pigs were studied. In bronchial smooth muscle rings that were precontracted with 10−5M acetylcholine, significant relaxation occurred with 10−8to 3 × 10−6M isoproterenol but not with 10−8to 10−3M furosemide. In contrast, bronchial arteries that were precontracted with either 10−4M norepinephrine or 10−8M vasopressin significantly relaxed in response to 10−4to 3 × 10−3M and 10−3to 3 × 10−3M furosemide, respectively. We conclude that furosemide, under the described experimental conditions, relaxes airway vascular smooth muscle but not bronchial smooth muscle. These results are consistent with previous suggestions that inhaled furosemide increases blood flow to airway tissues (Gilbert IA, Lenner KA, Nelson JA, Wolin AD, and Fouke JM.J Appl Physiol76: 409–415, 1994).