Chromatin 'programming' by sequence--is there more to the nucleosome code than %GC?
Chromatin 'programming' by sequence--is there more to the nucleosome code than %GC?
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DOI：
10.1186/jbiol207
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发表时间：
2009
影响因子：
--
通讯作者：
Rando OJ
中科院分区：
文献类型：
--
作者：
Hughes A;Rando OJ
基因组序列在指导真核生物基因组包装成染色质中的作用一直是最近相当多的辩论的主题。Tillo和Hughes的一篇新论文表明，酵母基因组中给定序列对组蛋白八聚体的内在热力学偏好可以在很大程度上用一个简单的模型来捕获，实际上主要由%GC来解释。因此，从基因组序列预测核小体占有率的规则比所声称的要简单得多。参见研究文章http://www.biomedcentral.com/1471-2105/10/442
The role of genomic sequence in directing the packaging of eukaryotic genomes into chromatin has been the subject of considerable recent debate. A new paper from Tillo and Hughes shows that the intrinsic thermodynamic preference of a given sequence in the yeast genome for the histone octamer can largely be captured with a simple model, and in fact is mostly explained by %GC. Thus, the rules for predicting nucleosome occupancy from genomic sequence are much less complicated than has been claimed. See research article http://www.biomedcentral.com/1471-2105/10/442