Comparison of phenylephrine bolus and infusion methods in baroreflex measurements.
Comparison of phenylephrine bolus and infusion methods in baroreflex measurements.
复制标题
压力反射测量中去氧肾上腺素推注和输注方法的比较。
DOI：
10.1152/jappl.1990.69.3.962
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Richeson,JF
中科院分区：
文献类型：
--
作者：
Sullebarger,JT;Liang,CS;Woolf,PD;Willick,AE;Richeson,JF
去氧肾上腺素 (PE) 推注和输注方法均已用于测量人类压力反射敏感性。为了确定这两种方法是否产生相同的压力感受器敏感性值，我们通过推注和分级输注方法对 17 名正常受试者进行静脉 PE。压力感受反射敏感性由心动周期长度（R-R间隔）和收缩动脉压之间的线性关系的斜率确定。两种方法在同一受试者中产生相似的动脉压峰值增加和压力反射敏感性的可重复结果，但输注法测量的压力反射斜率 (9.9 +/- 0.7 ms/mmHg) 显着低于推注法测量的压力反射斜率 (22.5 +/- 1.8 ms/mmHg，P 小于 0.0001)。阿托品预处理消除了两种方法对 PE 的心率反应，而血浆儿茶酚胺不受两种 PE 给药方法的影响。纳洛酮预处理夸大了对 PE 的升压反应，并增加了对 PE 输注的血浆 β-内啡肽反应，但对压力反射敏感性没有影响。因此，我们的结果表明：1) PE 推注和输注方法对压力反射的激活虽然可重复，但并不等效，2) 压力感受反射引起的心率对压力逐渐增加的反应小于压力快速升高时的反应，3) 在两种方法中，心率反应都是由迷走神经介导的，4) 交感神经系统和内源性阿片系统在介导压力反射控制方面都没有显着作用。正常受试者的心率与高血压刺激的关系。
Phenylephrine (PE) bolus and infusion methods have both been used to measure baroreflex sensitivity in humans. To determine whether the two methods produce the same values of baroreceptor sensitivity, we administered intravenous PE by both bolus injection and graded infusion methods to 17 normal subjects. Baroreflex sensitivity was determined from the slope of the linear relationship between the cardiac cycle length (R-R interval) and systolic arterial pressure. Both methods produced similar peak increases in arterial pressure and reproducible results of baroreflex sensitivity in the same subjects, but baroreflex slopes measured by the infusion method (9.9 +/- 0.7 ms/mmHg) were significantly lower than those measured by the bolus method (22.5 +/- 1.8 ms/mmHg, P less than 0.0001). Pretreatment with atropine abolished the heart rate response to PE given by both methods, whereas plasma catecholamines were affected by neither method of PE administration. Naloxone pretreatment exaggerated the pressor response to PE and increased plasma beta-endorphin response to PE infusion but had no effect on baroreflex sensitivity. Thus our results indicate that 1) activation of the baroreflex by the PE bolus and infusion methods, although reproducible, is not equivalent, 2) baroreflex-induced heart rate response to a gradual increase in pressure is less than that seen with a rapid rise, 3) in both methods, heart rate response is mediated by the vagus nerves, and 4) neither the sympathetic nervous system nor the endogenous opiate system has a significant role in mediating the baroreflex control of heart rate to a hypertensive stimulus in normal subjects.