The Trypanosoma brucei zinc finger protein ZC3H18 is involved in differentiation
The Trypanosoma brucei zinc finger protein ZC3H18 is involved in differentiation
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DOI：
10.1016/j.molbiopara.2011.02.007
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发表时间：
2011-06-01
影响因子：
1.5
通讯作者：
Clayton, Christine
中科院分区：
文献类型：
--
作者：
Benz, Corinna;Mulindwa, Julius;Clayton, Christine
在哺乳动物细胞中，含有两个CCCH-锌指结构域的蛋白质结合加速了3‘-非翻译区富含AU元件的mRNAs的降解。三个CCCH锌指蛋白TbZFP 1、TbZFP 2和TbZFP 3已被证明在锥虫分化中起作用。我们在这里研究了另一种蛋白质ZC3H18，它含有两个CCCH锌指结构域。ZC3H18基因在血液形态中并不是必需的，但在体外分化模型中，ZC3H18基因的缺失推迟了血液形态锥虫向生长在采采蝇中的原环状锥体的转变。(C)2011爱思唯尔B.V.保留所有权利。
In mammalian cells, the degradation of mRNAs that have AU-rich elements in their 3'-untranslated regions is accelerated by the binding of proteins that contain two CCCH-zinc-finger-domains. Three CCCH zinc-finger proteins, TbZFP1, TbZFP2, and TbZFP3, have been shown to have roles in trypanosome differentiation. We here studied another protein, ZC3H18, which has two CCCH zinc finger domains. The ZC3H18 gene is not essential in bloodstream forms, but in an in vitro model of differentiation, depletion of ZC3H18 delayed the transformation of bloodstream-form trypanosomes to the procyclic form that grows in the Tsetse fly. (C) 2011 Elsevier B.V. All rights reserved.