What ocular and systemic variables affect choroidal circulation in healthy eyes.
What ocular and systemic variables affect choroidal circulation in healthy eyes.
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DOI：
10.1097/md.0000000000005102
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发表时间：
2016-10
期刊：
影响因子：
1.6
通讯作者：
Terasaki H
中科院分区：
文献类型：
--
作者：
Iwase T;Yamamoto K;Kobayashi M;Ra E;Murotani K;Terasaki H
本研究的目的是调查脉络膜血流与健康眼患者的全身和眼部变量之间的关系。在这项前瞻性横断面研究中，我们检查了241名健康日本受试者（92名男性和149名女性;平均年龄，37.8 ± 17.0岁）的241只眼睛。 平均模糊率，测量脉络膜的相对血流量，使用激光散斑血流图。通过二值化方法确定脉络膜的总横截面脉络膜、管腔和基质面积。我们研究脉络膜生物膜反应器和全身和眼部变量之间的相关性。脉络膜平均模糊率与年龄（r =-0.385，P <0.001）和脉络膜厚度（r = 0.264，P <0.001）相关。 脉络膜面积与脉络膜平均模糊率（r = 0.374，P <0.001）、年龄（r =-0.184，P = 0.004）、眼轴长度（r =-0.251，P <0.001）和脉络膜厚度（r = 0.468，P <0.001）相关。 管腔面积与脉络膜平均模糊率（r = 0.403，P <0.001）、年龄（r =-0.244，P <0.001）、眼轴长度（r =-0.218，P = 0.001）和脉络膜厚度（r = 0.435，P <0.001）相关。 在多元逐步回归分析中，年龄（β =-0.321，P <0.001）和管腔面积（β = 0.320，P <0.001）、心率（β = 0.136，P = 0.018）和平均眼灌注压（β = 0.126，P = 0.045）是指示脉络膜平均模糊率的独立因素。 此外，眼轴长度（β = −0.352，P <0.001）、脉络膜平均模糊率（β = 0.273，P <0.001）、年龄（β = −0.247，P <0.001）、性别（β = −0.226，P <0.001）和平均眼灌注压（β = 0.193，P = 0.002）是指示管腔面积的独立因素。 脉络膜血流量与管腔面积呈正相关，与年龄呈负相关。此外，管腔面积与年龄呈负相关。这表明，老化导致脉络膜血流量和管腔面积减少，并且作为老化效应的结果，脉络膜血流量减少与管腔面积减少相关。
The aim of the study was to investigate the relationship between choroidal blood flow and systemic and ocular variables in patients with healthy eyes. In this prospective cross-sectional study, we examined 241 eyes of 241 healthy Japanese subjects (92 males and 149 females; mean age, 37.8 ± 17.0 years). The mean blur rate, a measure of the relative blood flow of the choroid, was determined using laser speckle flowgraphy. The total cross-sectional choroidal, luminal, and stromal areas of the choroid were determined by the binarization method. We investigated the correlation between choroidal MBR and systemic and ocular variables. Choroidal mean blur rate correlated with age (r = −0.385, P < 0.001) and choroidal thickness (r = 0.264, P < 0.001). The choroidal area correlated with choroidal mean blur rate (r = 0.374, P < 0.001), age (r = −0.184, P = 0.004), axial length (r = −0.251, P < 0.001), and choroidal thickness (r = 0.468, P < 0.001). The luminal area correlated with choroidal mean blur rate (r = 0.403, P < 0.001), age (r = −0.244, P < 0.001), axial length (r = −0.218, P = 0.001), and choroidal thickness (r = 0.435, P < 0.001). On multiple stepwise regression analyses, age (β = −0.321, P < 0.001) and luminal area (β = 0.320, P < 0.001), heart rate (β = 0.136, P = 0.018), and mean ocular perfusion pressure (β = 0.126, P = 0.045) were independent factors indicating the choroidal mean blur rate. Furthermore, axial length (β = −0.352, P < 0.001), choroidal mean blur rate (β = 0.273, P < 0.001), age (β = −0.247, P < 0.001), gender (β = −0.226, P < 0.001), and mean ocular perfusion pressure (β = 0.193, P = 0.002) were independent factors indicating the luminal area. The choroidal blood flow positively correlated with the luminal area and negatively correlating with age. In addition, the luminal area was negative correlated with age. It is suggested that aging causes a reduction in choroidal blood flow and luminal area, and as a result of aging effect, decreased choroidal blood flow would correlate with decreased luminal area.