The role of fibrocytes in fibrotic diseases of the lungs and heart.
The role of fibrocytes in fibrotic diseases of the lungs and heart.
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DOI：
10.1186/1755-1536-4-2
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发表时间：
2011-01-10
期刊：
影响因子：
--
通讯作者：
Strieter RM
中科院分区：
文献类型：
--
作者：
Keeley EC;Mehrad B;Strieter RM
纤维化是组织损伤和炎症之后一系列复杂事件的最终结果。病理生理性纤维化会导致永久性瘢痕形成，并可能损害器官功能。纤维细胞是一种循环的、骨髓来源的祖细胞，通过血流从骨髓运输到受损器官，在那里分化为成纤维细胞和肌成纤维细胞，在生理性和异常纤维化中都发挥着关键作用。本文就纤维细胞在肺和心脏纤维化疾病中的作用作一综述，包括间质性肺疾病、哮喘、肺动脉高压、动脉粥样硬化和缺血性心肌病。
Fibrosis is the end result of a complex series of events that follow tissue injury and inflammation. Pathophysiologic fibrosis results in permanent scar formation, and can impair organ function. Fibrocytes are circulating, bone-marrow-derived progenitor cells that traffic from the bone marrow to the injured organ via the bloodstream, where they differentiate into fibroblasts and myofibroblasts, and play a pivotal role in both physiologic and aberrant fibrosis. In this review, we focus on the contribution of fibrocytes to fibrotic diseases of the lungs and the heart, including interstitial lung diseases, asthma, pulmonary hypertension, atherosclerosis and ischemic cardiomyopathy.