Ironing out cancer.
Ironing out cancer.
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DOI：
10.1158/0008-5472.can-10-3614
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发表时间：
2011-03-01
期刊：
影响因子：
11.2
通讯作者：
Torti FM
中科院分区：
文献类型：
--
作者：
Torti SV;Torti FM
最近出现了关于调节细胞铁在癌症生长、血管生成和转移中的作用的新见解。铁转运蛋白、铁调素、Lcn2 以及 STEAP 和 IRP 家族成员在癌症中的作用的发现为铁稳态在癌症生长和转移中的作用提供了特异性和分子定义。许多研究直接支持这些蛋白质在改变生物可利用铁方面的作用，而其他研究表明它们的至少一些作用与其在铁生物学中的作用无关。
New insights into the roles of proteins that regulate cellular iron in cancer growth, angiogenesis, and metastasis have recently emerged. Discoveries of the roles of ferroportin, hepcidin, Lcn2, and members of the STEAP and IRP families in cancer have provided specificity and molecular definition to the role of iron homeostasis in cancer growth and metastasis. A number of studies directly support a role of these proteins in modifying bio-available iron, while other studies suggest that at least some of their effects are independent of their role in iron biology.