Concept of left atrial pressure estimation using its pulsatile amplitude in the helical flow total artificial heart
Concept of left atrial pressure estimation using its pulsatile amplitude in the helical flow total artificial heart
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DOI：
10.1007/s10047-014-0788-7
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发表时间：
2014-09
影响因子：
1.3
通讯作者：
Sheng-Yuan Wu;I. Saito;T. Isoyama;Y. Inoue;Masami Sato;Shintaro Hara;Xinyang Li;Terumi Yurimoto;Haruka Murakami;Y. Kawase;T. Ono;Y. Abe
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文献类型：
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作者：
Sheng-Yuan Wu;I. Saito;T. Isoyama;Y. Inoue;Masami Sato;Shintaro Hara;Xinyang Li;Terumi Yurimoto;Haruka Murakami;Y. Kawase;T. Ono;Y. Abe
全人工心脏（TAH）需要生理控制来响应身体的代谢需求。迄今为止，1/R控制是一种可以控制静脉压的单一生理控制方法。为了实现植入式 1/R 控制系统，我们正在开发一种使用绝对压力传感器的新压力测量方法。为了找到一种无需校准即可正常工作的绝对压力传感器方法，提出了利用其脉动幅度估计左心房压力（LAP）的概念。用两只长期存活的山羊（其心脏被螺旋流 TAH 替换）来研究其可能性。在手动控制条件下，平均LAP（mLAP）与归一化脉动幅度（NPA）之间存在正相关关系。收缩百分比显示不会影响 mLAP 和 NPA 之间的关系。观察到不同脉率之间的分散。至于心输出量差异（QLD），即收缩期和舒张期之间的流速差异，除了低 QLD 之外，获得了类似的结果。在1/R控制条件下，mLAP和NPA之间可以获得较高的相关性。在使用个体山羊的相关函数估计mLAP时，测量的mLAP和估计的mLAP之间获得了相当好的相关性。尽管还需要进一步的研究，但事实证明 LAP 估计的概念是可能的。
The total artificial heart (TAH) requires physiological control to respond to the metabolic demand of the body. To date, 1/R control is a single physiological control method that can control venous pressure. To realize an implantable 1/R control system, we are developing a new pressure measuring method using absolute pressure sensor. To find a method for absolute pressure sensor, which went well without calibration, concept of left atrial pressure (LAP) estimation using its pulsatile amplitude was proposed. Its possibility was investigated with two long-term survived goats whose hearts were replaced with the helical flow TAHs. In manual control condition, there existed a positive relation between mean LAP (mLAP) and normalized pulsatile amplitude (NPA). Percent systole revealed not to affect the relationship between mLAP and NPA. Dispersion was observed between different pulse rates. As for cardiac output difference (QLD) that is the difference of flow rate between systolic and diastolic phases, similar results were obtained except in low QLDs. In the 1/R control condition, relatively high correlation between mLAP and NPA could be obtained. In estimation of mLAP using the correlating function of individual goat, fairly good correlation was obtained between measured mLAP and estimated mLAP. Despite that further studies are necessary, it was demonstrated that the concept of the LAP estimation could be possible.