Rostral anterior cingulate cortex dysfunction during error processing in schizophrenia
Rostral anterior cingulate cortex dysfunction during error processing in schizophrenia
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DOI：
10.1093/brain/awg056
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发表时间：
2003-03-01
期刊：
影响因子：
14.5
通讯作者：
Liddle, PF
中科院分区：
文献类型：
--
作者：
Laurens, KR;Ngan, ETC;Liddle, PF
先前的研究表明，精神分裂症患者在内部监测对刺激的错误反应的能力受损。错误诱发任务的事件相关电位（ERP）研究表明，在健康成年人中，错误反应的发生与额中央分布的负电压成分有关，称为错误负波（Ne）或错误相关负波（ERN）。在精神分裂症患者中，Ne/ERN引起的错误的委员会（EoC）的幅度降低引起的健康参与者相比。功能性磁共振成像（fMRI）研究和ERP数据的源定位分析表明，EoC与头端前扣带皮层（ACC）的活动有关。使用事件相关功能磁共振成像，我们检查了一组10名精神分裂症患者和16名匹配的健康参与者与EoC相关的大脑活动。患者是从社区招募的病情稳定、部分缓解、接受药物治疗的门诊患者。参与者执行Go/NoGo任务变体，该变体先前显示在精神分裂症患者相对于健康参与者的EoC期间引起Ne/ERN降低，以及在健康参与者的EoC期间引起强烈的喙侧ACC激活。精神分裂症患者的特点是在头侧ACC与健康参与者相比，相对活动不足。还有证据表明，大脑边缘系统的活动更普遍。与这些相对活动减退的区域相反，在EoC和正确拒绝NoGo试验期间，精神分裂症患者的双侧顶叶皮层相对于健康参与者表现出活动过度。我们的研究结果与以前的ERP研究表明精神分裂症的错误处理过程中的功能异常是一致的。鉴于喙侧ACC和其他边缘系统结构在调节情感和动机行为中的作用，我们的研究结果表明，精神分裂症患者的错误可能会引起情感或动机反应的紊乱。
Previous research has demonstrated that patients with schizophrenia have an impaired ability to monitor erroneous responses to stimuli internally. Event-related potential (ERP) studies of error-eliciting tasks indicate that, in healthy adults, the commission of an erroneous response is associated with a fronto-centrally distributed negative voltage component termed the error negativity (Ne) or error-related negativity (ERN). In patients with schizophrenia, the Ne/ERN elicited by errors of commission (EoC) is reduced in amplitude compared with that elicited in healthy participants. Functional MRI (fMRI) studies and source localization analyses of ERP data in healthy participants suggest that EoC are associated with activity in the rostral anterior cingulate cortex (ACC). Using event-related fMRI, we examined the brain activity associated with EoC in a group of 10 patients with schizophrenia and 16 matched healthy participants. Patients were stable, partially remitted, medicated out-patients recruited from the community. Participants performed a Go/NoGo task variant that was shown previously to elicit a reduced Ne/ERN during EoC in patients with schizophrenia relative to healthy participants, as well as robust rostral ACC activation during EoC in healthy participants. Patients with schizophrenia were characterized by relative underactivity in the rostral ACC compared with healthy participants. There was also evidence for more widespread underactivity in the limbic system. In contrast to these regions of relative hypoactivity, patients with schizophrenia demonstrated hyperactivity relative to healthy participants in bilateral parietal cortex during both EoC and correctly rejected NoGo trials. Our results are consistent with previous ERP research demonstrating functional abnormalities during error processing in schizophrenia. In light of the role of the rostral ACC and other limbic structures in mediating affective and motivational behaviour, our results suggest there may be a disturbed affective or motivational response to the commission of errors in schizophrenia.