Metastasis-Initiating Cells and Ecosystems.
Metastasis-Initiating Cells and Ecosystems.
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DOI：
10.1158/2159-8290.cd-21-0010
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发表时间：
2021-04
期刊：
影响因子：
28.2
通讯作者：
Ganesh K
中科院分区：
文献类型：
--
作者：
Massagué J;Ganesh K
转移通过具有干细胞样和免疫逃避特性的癌细胞（称为转移起始细胞（MIC））的治疗来启动和维持。最近的进展表明，MIC的结果，通过恶性细胞的正常再生祖细胞表型，表型与内在程序生存的压力转移过程中，经历上皮-间充质转化，进入缓慢的循环状态休眠，逃避免疫监视，建立支持性的相互作用与器官特异性壁龛，并增选全身因素治疗后的生长和复发。对MIC表型和宿主组织生态系统的分子介质的机制理解可以产生癌症治疗方法来改善患者的结果。
Metastasis is initiated and sustained through therapy by cancer cells with stem-like and immune evasive properties, termed metastasis initiating cells (MICs). Recent progress suggests that MICs result from the adoption of a normal regenerative progenitor phenotype by malignant cells, a phenotype with intrinsic programs to survive the stresses of the metastatic process, undergo epithelial-mesenchymal transitions, enter slow-cycling states for dormancy, evade immune surveillance, establish supportive interactions with organ-specific niches, and co-opt systemic factors for growth and recurrence after therapy. Mechanistic understanding of the molecular mediators of MIC phenotypes and host tissue ecosystems could yield cancer therapeutics to improve patient outcomes.