EFFICIENT METHOD FOR THE PREPARATION OF 2-ALPHA,3-BETA-DICHLORO-4,4,10-TRIMETHYL-DECALIN SYSTEMS AS A ROUTE FOR THE SYNTHESIS OF DICHLOROLISSOCLIMIDE
EFFICIENT METHOD FOR THE PREPARATION OF 2-ALPHA,3-BETA-DICHLORO-4,4,10-TRIMETHYL-DECALIN SYSTEMS AS A ROUTE FOR THE SYNTHESIS OF DICHLOROLISSOCLIMIDE
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DOI：
10.1016/s0040-4039(00)60473-2
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发表时间：
1993-04-30
影响因子：
1.8
通讯作者：
GOMEZ, AV
中科院分区：
文献类型：
--
作者：
JUNG, ME;GOMEZ, AV
描述了双赤道二氯化三甲基十氢化萘衍生物的有效合成，该衍生物是强细胞毒性剂二氯利索酰亚胺 1 的 AB 环的类似物。关键步骤涉及热双轴到双赤道二氯化物重排，产率良好。
An efficient synthesis of diequatorial dichlorinated trimethyldecalin derivatives, analogues of the AB ring of the strongly cytotoxic agent dichlorolissoclimide 1, is described. The key step involves a thermal diaxial to diequatorial dichloride rearrangement in good yield.