Exercise increases BDNF levels in the striatum and decreases depressive-like behavior in chronically stressed rats
Exercise increases BDNF levels in the striatum and decreases depressive-like behavior in chronically stressed rats
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DOI：
10.1007/s11011-009-9157-2
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发表时间：
2009-12-01
影响因子：
3.6
通讯作者：
Daniels, Willie M. U.
中科院分区：
文献类型：
--
作者：
Marais, Lelanie;Stein, Dan J.;Daniels, Willie M. U.
人类早期的生活压力会影响神经元和神经递质系统的发育，并使个体容易患上抑郁症。同样，在大鼠中，母亲分离会导致焦虑和抑郁样行为以及皮质酮水平下降。接受药物治疗抑郁症的患者往往会遇到负面的副作用或没有最佳的反应，因此，使用运动作为替代抗抑郁治疗进行了研究。本研究的目的是观察早期生活应激和后期生活慢性应激的大鼠在慢性自愿运动治疗后是否表现出抑郁样行为、神经营养因子水平、应激激素水平和血清抗氧化能力的差异。将大鼠幼仔与母体分开，一组大鼠允许接触转轮6周，而对照组大鼠也进行处理并放入没有转轮的笼中。所有大鼠在成年期均受到慢性束缚应激。强迫游泳测试是为了测试抑郁样行为。测量腹侧海马和纹状体中的神经营养因子;测量血浆中的基线应激激素以及血清的抗氧化潜力。与对照组相比，运动大鼠的基线应激激素没有差异，但在强迫游泳试验中减少了不动时间，增加了纹状体中的脑源性神经营养因子（BDNF）水平，降低了血清的抗氧化能力。抑郁样行为改善的机制可能是通过增加纹状体BDNF水平介导的，从而增加神经可塑性并防止神经元死亡。
Early life stress in humans can affect the development of neurons and neurotransmitter systems and predispose an individual to the subsequent development of depression. Similarly, in rats, maternal separation causes anxiety and depressive-like behavior and decreased corticosterone levels. Patients receiving pharmacological treatment for depression often experience negative side-effects or do not respond optimally and therefore the use of exercise as alternative antidepressant treatment is investigated. The aim of the study was to see whether rats subjected to both early life stress and chronic stress later in life show differences in depressive-like behavior, neurotrophin levels, stress hormone levels and antioxidant capacity of serum after chronic voluntary exercise as treatment. Rat pups were maternally separated and one group were allowed access to running wheels for 6 weeks while control rats were also handled and put in cages without running wheels. All rats were subjected to chronic restraint stress during adulthood. A forced swim test was done to test for depressive-like behavior. Neurotrophins were measured in the ventral hippocampus and striatum; baseline stress hormones were measured in blood plasma as well as the anti-oxidative potential of serum. Compared to controls, rats that exercised had no difference in baseline stress hormones, but had decreased immobility times in the forced swim test, increased brain derived neurotrophic factor (BDNF) levels in the striatum and decreased anti-oxidative potential of their serum. The mechanism by which depressive-like behavior was improved may have been mediated through increased striatal BDNF levels, resulting in increased neuroplasticity and the prevention of neuronal death.