Restricted Replication of Xenotropic Murine Leukemia Virus-Related Virus in Pigtailed Macaques
Restricted Replication of Xenotropic Murine Leukemia Virus-Related Virus in Pigtailed Macaques
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DOI：
10.1128/jvi.06886-11
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发表时间：
2012-03-01
影响因子：
5.4
通讯作者：
Lifson, Jeffrey D.
中科院分区：
文献类型：
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作者：
Del Prete, Gregory Q.;Kearney, Mary F.;Lifson, Jeffrey D.
虽然异嗜性鼠白血病病毒相关病毒（XMRV）以前已与前列腺癌和肌痛性脑脊髓炎/慢性疲劳综合征，最近的数据表明，结果解释为人类XMRV感染的证据反映了实验室污染，而不是真实的体内感染。然而，XMRV是一种致病潜力不明确的逆转录病毒，能够在人类细胞中复制。在这里，我们描述了一个全面的分析，两个男性猪尾猕猴（猕猴nemestrina）实验感染XMRV。静脉内接种> 10（10）RNA拷贝当量的XMRV后，病毒复制有限且短暂，
Although xenotropic murine leukemia virus-related virus (XMRV) has been previously linked to prostate cancer and myalgic encephalomyelitis/chronic fatigue syndrome, recent data indicate that results interpreted as evidence of human XMRV infection reflect laboratory contamination rather than authentic in vivo infection. Nevertheless, XMRV is a retrovirus of undefined pathogenic potential that is able to replicate in human cells. Here we describe a comprehensive analysis of two male pigtailed macaques (Macaca nemestrina) experimentally infected with XMRV. Following intravenous inoculation with > 10(10) RNA copy equivalents of XMRV, viral replication was limited and transient, peaking at