Tick-Borne Relapsing Fever Spirochetes in the Americas.
Tick-Borne Relapsing Fever Spirochetes in the Americas.
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DOI：
10.3390/vetsci3030016
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发表时间：
2016-01-01
影响因子：
2.4
通讯作者：
Bermudez, Sergio
中科院分区：
文献类型：
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作者：
Lopez, Job E;Krishnavahjala, Aparna;Bermudez, Sergio
复发热螺旋体是蜱虫和虱传播的病原体，主要困扰贫困国家的人们。从历史上看，病原体对公共卫生产生了重大影响，但目前它们往往被忽视，因为疾病的非特异性显示。在这篇综述中，我们讨论了回归热（RF）螺旋体的发病机制，包括：（1）疾病的临床表现;（2）诊断病原体暴露的能力;（3）病原体在蜱和哺乳动物中的生命周期;（4）生态因素有助于RF螺旋体在自然界中的维持。
Relapsing fever spirochetes are tick- and louse-borne pathogens that primarily afflict those in impoverished countries. Historically the pathogens have had a significant impact on public health, yet currently they are often overlooked because of the nonspecific display of disease. In this review, we discuss aspects of relapsing fever (RF) spirochete pathogenesis including the: (1) clinical manifestation of disease; (2) ability to diagnose pathogen exposure; (3) the pathogen's life cycle in the tick and mammal; and (4) ecological factors contributing to the maintenance of RF spirochetes in nature.