Menopausal symptoms and bone health in women undertaking risk reducing bilateral salpingo-oophorectomy: significant bone health issues in those not taking HRT
Menopausal symptoms and bone health in women undertaking risk reducing bilateral salpingo-oophorectomy: significant bone health issues in those not taking HRT
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DOI：
10.1038/bjc.2011.202
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发表时间：
2011-06-28
影响因子：
8.8
通讯作者：
Evans, D. G.
中科院分区：
文献类型：
--
作者：
Challberg, J.;Ashcroft, L.;Evans, D. G.
背景技术背景：卵巢癌高风险的女性，特别是那些BRCA 1/BRCA 2突变的女性，鼓励在自然绝经前进行双侧输卵管卵巢切除术（BRRSPO）。由于要平衡乳腺癌风险、骨骼和心血管健康的考虑，因此很难决定使用HRT来覆盖50岁以下的雌激素剥夺期。方法：我们通过问卷调查对289名年龄≥ 24个月的BRRSPO后的女性进行了回顾性研究
BACKGROUND: Women at high ovarian cancer risk, especially those with mutations in BRCA1/BRCA2, are encouraged to undergo bilateral risk-reducing salpingo-oophorectomy (BRRSPO) prior to the natural menopause. The decision to use HRT to cover the period of oestrogen deprivation up to 50 years of age is difficult because of balancing the considerations of breast cancer risk, bone and cardiovascular health.METHODS: We reviewed by questionnaire 289 women after BRRSPO aged = 24 months of oestrogen deprivation