Effect of a Low-Glycemic Load Diet Intervention on Maternal and Pregnancy Outcomes in Obese Pregnant Women.
Effect of a Low-Glycemic Load Diet Intervention on Maternal and Pregnancy Outcomes in Obese Pregnant Women.
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DOI：
10.3390/nu13030748
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发表时间：
2021-02-26
期刊：
影响因子：
5.9
通讯作者：
King JC
中科院分区：
文献类型：
--
作者：
Goletzke J;De Haene J;Stotland NE;Murphy EJ;Perez-Rodriguez M;King JC
肥胖的患病率增加，孕妇有较高的葡萄糖耐受不良的风险，需要营养干预，以改善母体葡萄糖稳态。在这项研究中，在肥胖女性（体重指数（BMI）> 30或体脂>35%）的妊娠后半期，比较了低血糖负荷（GL）（n = 28）和高血糖负荷（n = 34）饮食干预的效果。在基线（20周）以及妊娠28周和34周时评估人体测量和代谢参数。对于主要结局3 h-葡萄糖-iAUC（3 h-增量曲线下面积），每个研究时间点的平均组间差异均不显著（第20、28和34周时分别为p = 0.6、0.3和0.8），并且评估了研究期间的平均变化（p = 0.6）。此外，两个干预组之间的任何其他检查结果均无统计学显著差异（p ≥ 0.07）。在汇总队列中，饮食GL对任何代谢或人体测量结果均无显著影响（p ≥ 0.2）。一项事后分析将研究妇女与仅接受常规护理的超重或肥胖孕妇队列进行了比较，结果显示，非研究妇女更有可能体重增加（p = 0.046），并分娩出大于胎龄儿（LGA）（p = 0.01）或巨大儿（p = 0.006）。因此，在怀孕的后半期摄入低GL饮食并不能改善肥胖妇女的妊娠结局，但与非研究妇女相比，饮食咨询降低了不良结局的风险。
The increased prevalence of obese, pregnant women who have a higher risk of glucose intolerance warrants the need for nutritional interventions to improve maternal glucose homeostasis. In this study, the effect of a low-glycemic load (GL) (n = 28) was compared to a high-GL (n = 34) dietary intervention during the second half of pregnancy in obese women (body mass index (BMI) > 30 or a body fat >35%). Anthropometric and metabolic parameters were assessed at baseline (20 week) and at 28 and 34 weeks gestation. For the primary outcome 3h-glucose-iAUC (3h-incremental area under the curve), mean between-group differences were non-significant at every study timepoint (p = 0.6, 0.3, and 0.8 at 20, 28, and 34 weeks, respectively) and also assessing the mean change over the study period (p = 0.6). Furthermore, there was no statistically significant difference between the two intervention groups for any of the other examined outcomes (p ≥ 0.07). In the pooled cohort, there was no significant effect of dietary GL on any metabolic or anthropometric outcome (p ≥ 0.2). A post hoc analysis comparing the study women to a cohort of overweight or obese pregnant women who received only routine care showed that the non-study women were more likely to gain excess weight (p = 0.046) and to deliver large-for-gestational-age (LGA) (p = 0.01) or macrosomic (p = 0.006) infants. Thus, a low-GL diet consumed during the last half of pregnancy did not improve pregnancy outcomes in obese women, but in comparison to non-study women, dietary counseling reduced the risk of adverse outcomes.
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影响因子：
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作者：
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