Autophagy as a melanocytic self-defense mechanism.
Autophagy as a melanocytic self-defense mechanism.
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DOI：
10.1038/jid.2015.19
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发表时间：
2015-05
期刊：
影响因子：
--
通讯作者：
Setaluri V
中科院分区：
文献类型：
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作者：
Setaluri V
自噬缺陷对黑素细胞存活和皮肤色素性疾病的表现有影响。显示缺乏自噬蛋白Atg 7的小鼠黑素细胞在体外经历过早衰老并积累氧化损伤产物，尽管氧化还原反应被激活。有趣的是，与之前的研究结果相反，自噬中黑素细胞特异性的缺陷并没有导致黑素体生物发生的重大缺陷，也没有产生小鼠毛色的视觉显着变化。
Defects in autophagy have implications for melanocyte survival and manifestations of skin pigmentary disorders. show that mouse melanocytes lacking the autophagy protein Atg7 undergo premature senescence in vitro and accumulate products of oxidative damage, despite activation of the redox response. Interestingly, contrary to previous findings, the melanocyte-specific deficiency in autophagy did not cause major defects in melanosome biogenesis, nor did it produce visually striking changes in mouse coat color.