High blood glutamate oxaloacetate transaminase levels are associated with good functional outcome in acute ischemic stroke
High blood glutamate oxaloacetate transaminase levels are associated with good functional outcome in acute ischemic stroke
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DOI：
10.1038/jcbfm.2011.4
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发表时间：
2011-06-01
影响因子：
6.3
通讯作者：
Castillo, Jose
中科院分区：
文献类型：
--
作者：
Campos, Francisco;Sobrino, Tomas;Castillo, Jose
在实验模型中，已证明血液酶谷氨酸草酰乙酸转氨酶（GOT）通过血液谷氨酸降解从大脑中清除谷氨酸的能力是预防缺血性卒中的有效和新型神经保护工具;然而，这种酶的有益作用应在卒中患者中进行测试，以验证这些结果。本研究旨在探讨急性缺血性卒中患者血液中GOT水平与临床结局的关系。在两项独立的临床研究中，我们发现预后不良的患者在入院时血液中谷氨酸水平较高，GOT水平较低。低GOT水平和高谷氨酸水平与3个月时较差的功能结局和较高的梗死体积独立相关。这些研究结果表明，高血谷氨酸水平和更差的结果之间存在明确的关联，反之亦然，GOT，大概解释了这种酶代谢血谷氨酸的能力。Journal of Cerebral Blood Flow & Metabolism（2011）31，1387-1393; doi：10.1038/jcbfm.2011.4; 2011年1月26日在线发表
The capacity of the blood enzyme glutamate oxaloacetate transaminase ( GOT) to remove glutamate from the brain by means of blood glutamate degradation has been shown in experimental models to be an efficient and novel neuroprotective tool against ischemic stroke; however, the beneficial effects of this enzyme should be tested in patients with stroke to validate these results. This study aims to investigate the association of GOT levels in blood with clinical outcome in patients with acute ischemic stroke. In two clinical independent studies, we found that patients with poor outcome show higher glutamate and lower GOT levels in blood at the time of admission. Lower GOT levels and higher glutamate levels were independently associated with poorer functional outcome at 3 months and higher infarct volume. These findings show a clear association between high blood glutamate levels and worse outcome and vice versa for GOT, presumably explained by the capacity of this enzyme to metabolize blood glutamate. Journal of Cerebral Blood Flow & Metabolism (2011) 31, 1387-1393; doi:10.1038/jcbfm.2011.4; published online 26 January 2011