Oscillometric measurement of systolic and diastolic blood pressures validated in a physiologic mathematical model.
Oscillometric measurement of systolic and diastolic blood pressures validated in a physiologic mathematical model.
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DOI：
10.1186/1475-925x-11-56
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发表时间：
2012-08-22
影响因子：
3.9
通讯作者：
Babbs CF
中科院分区：
文献类型：
--
作者：
Babbs CF
用自动袖带测量血压的血压计方法产生平均压力的有效估计，但收缩压和舒张压的估计有问题。现有算法对脉压和动脉硬度的差异敏感。有些是严格保密的商业机密。从袖带压力振荡的包络中准确提取收缩压和舒张压仍然是生物医学工程中的一个开放性问题。对相关解剖学、生理学和物理学的新分析揭示了袖带压力振荡产生的机制，以及从任何个体受试者的振荡包络中提取收缩压和舒张压的方法。可以从包络形状中提取压缩动脉段的刚度特性，以创建个性化的数学模型。该模型用可能的收缩压和舒张压值的矩阵进行测试，并且观察到的和预测的包络函数之间的最小最小二乘差指示测试矩阵内的收缩压和舒张压的最佳拟合选择。该模型再现了真实的袖带压力振荡。回归过程在面对不同的脉压和动脉僵硬度时准确地提取收缩压和舒张压。在一系列具有挑战性的测试场景中，提取的收缩压和舒张压的均方根误差为0.3 mmHg。一种基于物理学和生理学的新算法可以从袖带压力振荡中准确提取收缩压和舒张压，这种方法可以在公共领域进行验证、批评和更新。
The oscillometric method of measuring blood pressure with an automated cuff yields valid estimates of mean pressure but questionable estimates of systolic and diastolic pressures. Existing algorithms are sensitive to differences in pulse pressure and artery stiffness. Some are closely guarded trade secrets. Accurate extraction of systolic and diastolic pressures from the envelope of cuff pressure oscillations remains an open problem in biomedical engineering. A new analysis of relevant anatomy, physiology and physics reveals the mechanisms underlying the production of cuff pressure oscillations as well as a way to extract systolic and diastolic pressures from the envelope of oscillations in any individual subject. Stiffness characteristics of the compressed artery segment can be extracted from the envelope shape to create an individualized mathematical model. The model is tested with a matrix of possible systolic and diastolic pressure values, and the minimum least squares difference between observed and predicted envelope functions indicates the best fit choices of systolic and diastolic pressure within the test matrix. The model reproduces realistic cuff pressure oscillations. The regression procedure extracts systolic and diastolic pressures accurately in the face of varying pulse pressure and arterial stiffness. The root mean squared error in extracted systolic and diastolic pressures over a range of challenging test scenarios is 0.3 mmHg. A new algorithm based on physics and physiology allows accurate extraction of systolic and diastolic pressures from cuff pressure oscillations in a way that can be validated, criticized, and updated in the public domain.