Biologically active atrial peptides.
Biologically active atrial peptides.
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具有生物活性的心房肽。
DOI：
10.1172/jci112206
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Brenner,BM
中科院分区：
文献类型：
--
作者：
Ballerman,BJ;Brenner,BM
术语心房因子，现在已知是一种多肽，被不同地命名为心房利钠因子(8)、心钠素多肽(9)、心钠素(10)、心钠素(11)、耳廓蛋白(12)和阿特林(13)。此外，从心房中还分离到了几种不同分子量的利钠肽。具有利钠活性的Var-IOUS心房肽具有共同的氨基酸序列，仅在NH2末端和Cogh末端延伸的长度上存在差异(表I)。为清楚起见，本综述将使用通用术语atrin来指代所有这些多肽。每个不同多肽的特定序列将由下标表示，atrin，28用作参考部分。当不打算或不需要引用特定序列时，将使用通用术语atrin。
Terminology The atrial factor, now known to be a polypeptide, has variously been termed atrial natriuretic factor (8), atrial natriuretic polypeptide (9), cardionatrin (10), atriopeptin (11), auriculin (12), and atrin (13). Furthermore, several natriuretic peptides ofdifferent molecular weights have been isolated from atria. The var-ious atrial peptides possessing natriuretic activity share a common amino acid sequence, with differences emerging only in the length ofNH2-terminal and COGH-terminal extensions (Table I). For clarity, this review will refer to all ofthese peptides by the generic term atrin. The specific sequence for each distinct peptide will be indicated by subscripts, atrin, 28 serving as the reference moiety. When reference to a specific sequence is not intended or required, the general term atrin will be used.