Expression of NKX3.1 in normal and malignant tissues
Expression of NKX3.1 in normal and malignant tissues
复制标题
DOI：
10.1002/pros.10210
复制
发表时间：
2003-05-01
期刊：
影响因子：
2.8
通讯作者：
Bubendorf, L
中科院分区：
文献类型：
--
作者：
Gelmann, EP;Bowen, C;Bubendorf, L
背景NKX3.1是NK类同源结构域蛋白的一员，主要在成人前列腺中表达，对前列腺上皮细胞具有生长抑制和分化作用。我们对4，061个样本进行了NKX3.1和PSA表达的免疫组织化学分析，这些样本包括在一个广谱人类癌症和正常组织的组织微阵列中。NKX3.1表达见于前列腺上皮细胞、前列腺癌、正常睾丸、9%的原发性和5%的转移性浸润性导管乳腺癌、27%的原发性和26%的转移性浸润性小叶乳腺癌。在474例原发性乳腺癌患者中，中位随访生存期超过62.5个月，我们发现NKX3.1表达对预后没有影响。NKX3.1的表达比前列腺特异性抗原的表达谱更受限制。NKX3.1的表达是高度受限的，主要见于良性和恶性前列腺上皮细胞，也见于正常睾丸和乳腺小叶癌。(C)2003 Wiley-Liss，Inc.
BACKGROUND. NKX3.1, a member of the NK-class of homeodomain proteins, is expressed primarily in the adult prostate and has growth suppression and differentiating effects in prostate epithelial cells.METHODS. We performed immumohistochemical analysis for NKX3.1 and PSA expression in 4,061 samples included in a tissue microarray of a broad spectrum of human cancers and normal tissues.RESULTS. NKX3.1 expression was seen in prostate epithelial cells, prostate cancer, normal testis, 9% of primary and 5% of metastatic infiltrating ductal breast carcinoma, and 27% of primary and 26% of metastatic infiltrating lobular breast carcinoma. In a cohort of 474 primary breast cancers with median follow-up over 62.5 month survival, we found no effect of NKX3.1 expression on prognosis. NKX3.1 expression was more restricted than the spectrum of prostate specific antigen expression.CONCLUSIONS. Expression of NKX3.1 is highly restricted and is found primarily in benign and malignant prostatic epithelial cells and also in normal testis and lobular carcinoma of the breast. (C) 2003 Wiley-Liss, Inc.