Toward Primary Prevention of Asthma Reviewing the Evidence for Early-Life Respiratory Viral Infections as Modifiable Risk Factors to Prevent Childhood Asthma
Toward Primary Prevention of Asthma Reviewing the Evidence for Early-Life Respiratory Viral Infections as Modifiable Risk Factors to Prevent Childhood Asthma
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DOI：
10.1164/rccm.201405-0901pp
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发表时间：
2015-01-01
影响因子：
24.7
通讯作者：
Hartert, Tina V.
中科院分区：
文献类型：
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作者：
Feldman, Amy S.;He, Yuan;Hartert, Tina V.
初级疾病预防的第一步是确定导致很大一部分疾病发展的共同的、可改变的风险因素。婴儿呼吸道病毒感染和儿童哮喘分别是儿童最常见的急慢性疾病。这些疾病之间的共同临床特征和联系早已被认识到，生命早期呼吸道合胞病毒（RSV）和鼻病毒（RV）下呼吸道感染（LRTIs）与哮喘风险增加密切相关。然而，关于这些呼吸道病毒在哮喘发病中的作用一直存在争议。在本文中，我们系统地回顾了生命早期RSV和RV LRTIs与哮喘发病之间的联系，以及它们是否因此可以成为初级预防工作的目标。
A first step in primary disease prevention is identifying common, modifiable risk factors that contribute to a significant proportion of disease development. Infant respiratory viral infection and childhood asthma are the most common acute and chronic diseases of childhood, respectively. Common clinical features and links between these diseases have long been recognized, with early-life respiratory syncytial virus (RSV) and rhinovirus (RV) lower respiratory tract infections (LRTIs) being strongly associated with increased asthma risk. However, there has long been debate over the role of these respiratory viruses in asthma inception. In this article, we systematically review the evidence linking early-life RSV and RV LRTIs with asthma inception and whether they could therefore be targets for primary prevention efforts.