Effects of ACE inhibitors on insulin resistance and lipid profile in children with metabolic syndrome.
Effects of ACE inhibitors on insulin resistance and lipid profile in children with metabolic syndrome.
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DOI：
10.4274/jcrpe.1020
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发表时间：
2013-09-10
影响因子：
1.9
通讯作者：
Akçay T
中科院分区：
文献类型：
--
作者：
Bitkin EC;Boyraz M;Taşkın N;Akçay A;Ulucan K;Akyol MB;Akçay T
目的：本研究的目的是评估使用ACE抑制剂对10岁以上肥胖相关代谢综合征（MS）儿童胰岛素抵抗、葡萄糖代谢、体脂组成和脂质谱的影响。方法：对53例多发性硬化症患儿进行随访，随访时间至少1年。将样本分为两组：1-30组肥胖儿童（13名女性，17名男性）未使用ACE抑制剂；2-23组肥胖儿童（13名女性，10名男性）使用ACE抑制剂。比较两组患者在基线、第3、6、12个月随访时的人体测量和实验室数据。结果：两组患者在第3、6、12个月的数据比较显示，在体重标准差评分（SDS）、体重质量指数（SDS）、身高百分位数体重、体脂率、极低密度脂蛋白（VLDL）值方面无统计学差异。然而，在平均葡萄糖和胰岛素水平、胰岛素抵抗的稳态模型评估、LDL和高密度脂蛋白值、平均甘油三酯值方面存在显著差异。结论：ACE抑制剂药物的积极作用，特别是对高甘油三酯血症和胰岛素抵抗的积极作用，可能使其成为治疗肥胖和高血压儿童的一线药物。需要随机、对照、双盲和长期的研究才能得出明确的结论。利益冲突：没有声明。
Objective: The aim of this study was to evaluate the effects of using ACE inhibitors on insulin resistance, glucose metabolism, body fat composition, and lipid profile in children over 10 years of age with obesity-associated metabolic syndrome (MS). Methods: A total of 53 children with MS, who had been followed for at least one year were included in the study. The sample was divided into two groups: Group 1-30 obese children (13 female, 17 male) who were not using an ACE inhibitor and Group 2-23 obese children (13 female, 10 male) who were using an ACE inhibitor. Anthropometric and laboratory dataobtained at baseline and at the 3rd, 6th, and 12th months of follow-up were compared in the two groups. Results: Comparison of the data in the two groups at 3rd, 6th, and 12th months revealed no statistically significant differences in terms of weight standard deviation score (SDS), body mass index SDS, weight for height percentile, body fat percentage, and very low-density lipoprotein (VLDL)values. However, there were statistically significant differences in mean glucose and insulin levels, homeostasis model assessment for insulin resistance, LDL and high-density lipoprotein values, and highly significant differences in mean triglyceride values. Conclusions: The positive effects of ACE inhibitor drugs, particularly on hypertriglyceridemia and insulin resistance, might bring them forth as first-line drugs in the treatment of obese and hypertensive children. Randomized, controlled, double-blind, and long-term studies are needed for a definitive conclusion. Conflict of interest:None declared.