Efficient synthesis of pyrroles and 4,5,6,7-tetrahydroindoles via palladium-catalyzed oxidation of hydroxy-enamines
Efficient synthesis of pyrroles and 4,5,6,7-tetrahydroindoles via palladium-catalyzed oxidation of hydroxy-enamines
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DOI：
10.1016/j.tet.2006.06.070
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发表时间：
2006-09-04
期刊：
影响因子：
2.1
通讯作者：
Takeya, Koichi
中科院分区：
文献类型：
--
作者：
Aoyagi, Yutaka;Mizusaki, Toshihiko;Takeya, Koichi
建立了一种简便的一锅法合成多取代吡咯和4-氧代-4，5，6，7-四氢吲哚的方法，该方法包括三步：（1）钯催化的四（三苯基膦）钯-异亚丙基溴氧化体系氧化羟基烯胺，（2）分子内环化，（3）脱水。(c)2006爱思唯尔有限公司保留所有权利。
Facile and one-pot synthetic route of poly-substituted pyrroles and 4-oxo-4,5,6,7-tetrahydroindoles is established, which consists of three steps: (1) palladium-catalyzed oxidation of hydroxy-enamines by using tetrakis(triphenylphosphine)palladium and mesityl bromide oxidation system, (2) intramolecular cyclization, and (3) dehydration. (c) 2006 Elsevier Ltd. All rights reserved.