Improving neuropathy scores in type 2 diabetic patients using micronutrients supplementation
Improving neuropathy scores in type 2 diabetic patients using micronutrients supplementation
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DOI：
10.1016/j.diabres.2011.03.016
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发表时间：
2011-07-01
影响因子：
5.1
通讯作者：
Adelmanesh, Farhad
中科院分区：
文献类型：
--
作者：
Farvid, Maryam Sadat;Homayouni, Fatemeh;Adelmanesh, Farhad
目的：探讨补充微量营养素是否能改善2型糖尿病患者的神经病变指数。材料与方法：75例2型糖尿病患者随机、双盲、安慰剂对照临床试验，分为3组，每日补充锌20 mg、镁250 mg、维生素C 200 mg、维生素E 100 mg；MVB组：上述矿物质和维生素补充剂加维生素B1(10 Mg)、B2(10 Mg)、B6(10 Mg)、生物素(200 MU G)、B12(10 MU G)和叶酸(1 Mg)；P组：安慰剂。4个月后，MVB组、MV组和安慰剂组的神经病变症状从3.45改善到0.64(P=0.001)，MV从3.96改善到1.0(P=0.001)，安慰剂组从2.54改善到1.95。补充4个月后，3组间MNSI检查结果差异无统计学意义。治疗4个月后，MV组和MVB组患者的血糖控制、毛细血管血流和电生理指标与安慰剂组相比无明显变化。结论：补充微量营养素可改善糖尿病神经病变症状。(C)2011爱思唯尔爱尔兰有限公司。保留所有权利。
Aim: The aim of the present study was to determine if micronutrients supplementation can improve neuropathy indices in type 2 diabetes.Materials and methods: In this randomized, double-blind, placebo-controlled clinical trial, 75 type 2 diabetes patients were assigned to three treatment groups, receiving one of the following daily supplement for 4 months: Group MV: zinc (20 mg), magnesium (250 mg), vitamin C (200 mg) and E (100 mg); Group MVB: both of the above mineral and vitamin supplements plus vitamin B1 (10 mg), B2 (10 mg), B6 (10 mg), biotin (200 mu g), B12 (10 mu g) and folic acid (1 mg); Group P: placebo.Results: 67 patients completed the study. Neuropathic symptoms based on the MNSI questionnaire improved from 3.45 to 0.64 (p = 0.001) in group MVB, from 3.96 to 1.0 (p = 0.001) in group MV and from 2.54 to 1.95 in placebo group after 4 months. There was no significant difference between three treatment groups in MNSI examinations after 4 months supplementations. Over 4 months of treatment, patients showed no significant changes in glycemic control, capillary blood flow or electrophysiological measures in MV and MVB groups compared with placebo group.Conclusions: These studies suggest that micronutrients supplementation might ameliorate diabetic neuropathy symptoms. (C) 2011 Elsevier Ireland Ltd. All rights reserved.