Defining an intermediate category of tuberculin skin test: A mixture model analysis of two high-risk populations from Kampala, Uganda.
Defining an intermediate category of tuberculin skin test: A mixture model analysis of two high-risk populations from Kampala, Uganda.
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确定结核菌素皮试的中间类别： 对乌干达坎帕拉两个高危人群的混合模型分析。
DOI：
10.1371/journal.pone.0245328
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发表时间：
2021
期刊：
影响因子：
3.7
通讯作者：
Whalen CC
中科院分区：
文献类型：
--
作者：
Woldu HG;Zalwango S;Martinez L;Castellanos ME;Kakaire R;Sekandi JN;Kiwanuka N;Whalen CC
One principle of tuberculosis control is to prevent the development of tuberculosis disease by treating individuals with latent tuberculosis infection. The diagnosis of latent infection using the tuberculin skin test is not straightforward because of concerns about immunologic cross reactivity with the Bacille Calmette-Guerin (BCG) vaccine and environmental mycobacteria. To parse the effects of BCG vaccine and environmental mycobacteria on the tuberculin skin test, we estimated the frequency distribution of skin test results in two divisions of Kampala, Uganda, ten years apart. We then used mixture models to estimate parameters for underlying distributions and defined clinically meaningful criteria for latent infection, including an indeterminate category. Using percentiles of two underlying normal distributions, we defined two skin test readings to demarcate three ranges. Values of 10 mm or greater contained 90% of individuals with latent infection; values less than 7.2 mm contained 80% of individuals without infection. Contacts with values between 7.2 and 10 mm fell into an indeterminate zone where it was not possible to assign infection. We conclude that systematic tuberculin skin test surveys within populations at risk, combined with mixture model analysis, may be a reproducible, evidence-based approach to define meaningful criteria for latent tuberculosis infection.
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DOI：
10.1164/rccm.201409-1704oc
发表时间：
2015-03-01
影响因子：
24.7
作者：
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通讯作者：
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DOI：
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发表时间：
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影响因子：
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影响因子：
3.7
作者：
Kerkhoff AD;Kranzer K;Samandari T;Nakiyingi-Miiro J;Whalen CC;Harries AD;Lawn SD
通讯作者：
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影响因子：
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