Developments in the field of allergy in 2014 through the eyes of Clinical and Experimental Allergy
Developments in the field of allergy in 2014 through the eyes of Clinical and Experimental Allergy
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DOI：
10.1111/cea.12663
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发表时间：
2015-12
影响因子：
6.1
通讯作者：
B. Hales;Nobuyuki Hizawa;M. Jenmalm;E. Sverremark-Ekström;Andrew J. Wardlaw
中科院分区：
文献类型：
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作者：
B. Hales;Nobuyuki Hizawa;M. Jenmalm;E. Sverremark-Ekström;Andrew J. Wardlaw
哮喘的发病机制仍然是我们的作者感兴趣的一个主要课题，关于病毒的作用、炎症机制、生物标志物和哮喘表型的综述和原始论文是主要课题。许多论文描述了哮喘的新疗法，重点是阻断Th2反应，反映了这一领域二十年的工作终于取得成果。慢性鼻窦炎的发病机制是一个越来越受关注的领域，但与前几年相比，对气道疾病遗传学的研究较少，这可能反映了目前正在进行的这类研究的严格程度（因此工作量较小）。关于过敏性疾病的机制，从基于临床的研究到基础研究和体内动物模型（尤其是小鼠）的使用，仍然有大量的论文。和以前一样，免疫治疗的机制和新方法是共同的主题。在过敏原部分发表了一些研究过敏原的修饰，以增加其有效性并降低不良事件的风险。过敏性疾病的风险因素是流行病学部分的一个共同主题，食物过敏是临床过敏的一个共同主题，论文涉及诱导耐受性的方案开发，并试图找到区分致敏性和过敏性疾病的生物标志物。今年对编辑们来说又是激动人心的一年，我们希望杂志的读者。
The pathogenesis of asthma continues to be a major topic of interest to our authors with reviews and original papers on the role of viruses, mechanisms of inflammation, biomarkers, and phenotypes of asthma being major topics. A number of papers described new treatments for asthma focusing on blocking the Th2 response reflecting the fact that two decades of work in this area is finally bearing fruit. The pathogenesis of chronic rhinosinusitis is a growing area of interest, but there has been less on the genetics of airways disease than in previous years possibly reflecting the degree of rigour (and therefore a smaller body of work), with which these sorts of studies are now being undertaken. There continues to be a wide range of papers dealing with mechanisms of allergic disease ranging from clinical‐based studies to basic research and the use of in vivo animal models especially mice. As before, mechanisms and new approaches to immunotherapy are common themes. Several were published in the allergens section investigating modification of allergens to increase their effectiveness and reduce the risk of adverse events. Risk factors for allergic disease was a common theme in the epidemiology section and food allergy a common theme in clinical allergy with papers on the development of protocols to induce tolerance and attempts to find biomarkers to distinguish sensitization from allergic disease. This was another exciting year for the editors, and we hope the readers of the journal.