Control of Chromatin Structure by Long Noncoding RNA.
Control of Chromatin Structure by Long Noncoding RNA.
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DOI：
10.1016/j.tcb.2015.07.002
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发表时间：
2015-10
影响因子：
19
通讯作者：
Wierzbicki AT
中科院分区：
文献类型：
--
作者：
Böhmdorfer G;Wierzbicki AT
长链非编码RNA （lncRNA）是调控基因组各方面活性的关键因子。通过DNA甲基化和翻译后组蛋白修饰进行基因组调控是lncRNA在植物、真菌和动物中的一项充分证明的功能。在这里，我们总结证据表明lncRNA也控制染色质结构，包括核小体定位和染色体环。我们专注于从植物实验系统的数据，在其他真核生物的背景下讨论。我们解释了lncrna控制的染色质重塑机制以及非编码转录与几种不同染色质重塑因子之间功能相互作用的含义。我们认为RNA的独特性质使其适合于控制染色质修饰和结构。
Long noncoding RNA (lncRNA) is a pivotal factor regulating various aspects of genome activity. Genome regulation via DNA methylation and posttranslational histone modifications is a well-documented function of lncRNA in plants, fungi, and animals. Here, we summarize evidence showing that lncRNA also controls chromatin structure including nucleosome positioning and chromosome looping. We focus on data from plant experimental systems, discussed in the context of other eukaryotes. We explain the mechanisms of lncRNA-controlled chromatin remodeling and the implications of the functional interplay between noncoding transcription and several different chromatin remodelers. We propose that the unique properties of RNA make it suitable for controlling chromatin modifications and structure.