Assessing key safety concerns of a Wolbachia-based strategy to control dengue transmission by Aedes mosquitoes
Assessing key safety concerns of a Wolbachia-based strategy to control dengue transmission by Aedes mosquitoes
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DOI：
10.1590/s0074-02762010000800002
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发表时间：
2010-12-01
期刊：
影响因子：
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通讯作者：
O'Neill, Scott L
中科院分区：
文献类型：
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作者：
Popovici, Jean;Moreira, Luciano A;O'Neill, Scott L
登革热、基孔肯雅热或疟疾等蚊媒疾病每年影响数百万人，迫切需要控制解决方案。目前正在制定一项国际研究计划，该计划依赖于将细菌内共生体Wolbachia pipientis引入埃及伊蚊以控制登革热传播。为了准备沃尔巴克氏体感染的蚊子的开放现场测试释放，在北方澳大利亚的凯恩斯进行了密集的社会研究和社区参与计划。接受调查的各种社区成员和利益攸关方表达的最普遍的关切是，必须确保拟议方法对人类、动物和环境的安全。为了解决这些问题，进行了一系列安全性实验。我们在本文中获得的实验数据报告，讨论了实验风险评估的局限性，并专注于包括社区关注的科学研究的必要性。
Mosquito-borne diseases such as dengue fever, chikungunya or malaria affect millions of people each year and control solutions are urgently needed. An international research program is currently being developed that relies on the introduction of the bacterial endosymbiont Wolbachia pipientis into Aedes aegypti to control dengue transmission. In order to prepare for open-field testing releases of Wolbachia-infected mosquitoes, an intensive social research and community engagement program was undertaken in Cairns, Northern Australia. The most common concern expressed by the diverse range of community members and stakeholders surveyed was the necessity of assuring the safety of the proposed approach for humans, animals and the environment. To address these concerns a series of safety experiments were undertaken. We report in this paper on the experimental data obtained, discuss the limitations of experimental risk assessment and focus on the necessity of including community concerns in scientific research.