Vagus nerve stimulation does not lead to significant changes in body weight in patients with epilepsy
Vagus nerve stimulation does not lead to significant changes in body weight in patients with epilepsy
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DOI：
10.1016/j.yebeh.2005.10.001
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发表时间：
2006-02-01
影响因子：
2.6
通讯作者：
Holmes, MD
中科院分区：
文献类型：
--
作者：
Koren, MS;Holmes, MD
背景迷走神经刺激（VNS）是FDA批准的治疗难治性癫痫的方法。这种疗法对体重的影响尚不清楚。迷走神经刺激可通过胃肠道迷走神经传入介导饱腹感而引起体重减轻。方法.我们对VNS植入后2年内的体重变化进行了回顾性分析。我们研究了21例患者（13例男性/8例女性），年龄35 ± 12岁，在1998年4月至2004年5月期间接受了Cyberonics VNS治疗系统治疗难治性癫痫。平均SD随访持续时间为613.1 ± 389.1天。该研究具有80%的把握度，I类误差为0.05，可检测5%的体重变化。数据采用重复测量方差分析进行分析。结果第30、60、120、360、480和720天时相对于基线的体重变化分别为-0.17 +/- 2.33、+0.33 +/- 2.64、-0.32 +/- 3.56、+1.09 +/- 5.97、+1.06 +/- 7.47和+0.33 +/-3.69%。在所有时间点，这些差异均未达到统计学显著性。结论.采用癫痫患者治疗中常用的参数进行迷走神经刺激与临床显著的体重变化无关。一个良好的对照前瞻性研究是必要的，以更精确的评价迷走神经刺激治疗对体重的影响。(c)2005年爱思唯尔公司All rights reserved.
Background. Vagus nerve stimulation (VNS) is an FDA-approved treatment for medically intractable epilepsy. The effect of this therapy on body weight is unclear. VNS could cause weight loss by engaging vagal afferents from the gastrointestinal tract mediating satiety. Methods. We performed a retrospective analysis of body weight changes over a period up to 2 years following VNS implantation. We studied 21 patients (13 M/8 F) 35 +/- 12 years old, who received a Cyberonics VNS Therapy System for medically intractable epilepsy between April 1998 and May 2004. The mean SD duration of follow-up was 613.1 +/- 389.1 days. The study had 80% power with a type I error of 0.05 to detect a 5% weight change. Data were analyzed with repeated-measures ANOVA. Results. Weight changes relative to baseline at 30, 60, 120, 360, 480, and 720 days were -0.17 +/- 2.33, +0.33 +/- 2.64, -0.32 +/- 3.56, +1.09 +/- 5.97, +1.06 +/- 7.47, and +0.33 +/- 3.69%, respectively. At all time points these differences failed to reach statistical significance. Conclusions. Vagus nerve stimulation with parameters typically used in the treatment of patients with epilepsy was not associated with clinically significant weight changes. A well-controlled prospective study is necessary for more precise evaluation of the effect of VNS therapy on body weight. (c) 2005 Elsevier Inc. All rights reserved.