With the leisure of time, kinetic proofreading does reliable ligand discrimination after all
With the leisure of time, kinetic proofreading does reliable ligand discrimination after all
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有了闲暇，动力学校对毕竟做到了可靠的配体辨别
DOI：
10.1101/2024.01.11.575129
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发表时间：
2024
期刊：
影响因子：
--
通讯作者：
Vahe Galstyan
中科院分区：
文献类型：
--
作者：
Fangzhou Xiao;Vahe Galstyan
在最近的 PNAS 出版物中，Kirby 和 Zilman 认为，当考虑到随机性时，在动力学校对中采用更多步骤通常不会改善基于产生的信号分子计数对不同受体结合配体的区分 [1]。然而，他们的结论是基于一个重大技术错误，一旦纠正，就会与他们的主要结论相矛盾。此外，在整个分析过程中，作者隐含地假设歧视时间是固定的。我们在下面认为，为了更全面地理解，配体辨别的动力学校对应该在速度准确度权衡的背景下进行研究。
In a recent PNAS publication, Kirby and Zilman argued that when stochasticity is taken into account, having more steps in kinetic proofreading generally does not improve the discrimination of different receptor-binding ligands based on the counts of signaling molecules produced [1]. However, their conclusion is based on a major technical error that, once corrected, contradicts their main conclusion. Also, throughout their analysis, the authors made the implicit assumption that discrimination time is fixed. We argue below that, for a fuller understanding, kinetic proofreading for ligand discrimination should be studied in the context of speedaccuracy tradeoffs.
影响因子：
4.3
作者：
J. Morgan;A. Lindsay
通讯作者：
J. Morgan;A. Lindsay