Low-sound-level auditory processing in noise-exposed adults
Low-sound-level auditory processing in noise-exposed adults
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DOI：
10.1016/j.heares.2021.108309
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发表时间：
2021-07-30
期刊：
影响因子：
2.8
通讯作者：
Stone, Michael A.
中科院分区：
文献类型：
--
作者：
Perugia, Emanuele;Plack, Christopher J.;Stone, Michael A.
噪声引起的听力损伤的早期迹象很难识别，因为它们经常受到年龄，听力阈值甚至音乐体验等因素的混淆。以前的许多研究都集中在高强度水平下观察到的缺陷。与此相反，本研究的目的是测试的假设，噪声暴露导致低声级的听觉处理在人类中的退化，作为内毛细胞通路功能障碍的结果。在15和25 dB感觉水平（SL）下测量了5个中心频率（0.75，1，3，4和6 kHz）的频差阈（FDLs）和调幅深度辨别力（MDD），作为噪声暴露、年龄、听力损失和音乐体验的函数。对40名年龄在33-75岁之间的参与者进行了测试，他们的听力正常，最高可达1 kHz，轻度至中度听力损失超过2 kHz。参与者有不同程度的自我报告的噪音暴露，并在不同的音乐体验。FDL随着年龄的增长而恶化。有音乐经验的参与者在FDL和MDD任务中的表现优于无经验者。MDD阈值显着更好的高噪声暴露，比低噪声暴露，参与者在25 dB SL，特别是在6 kHz。在MDD中未观察到年龄或听力损失的影响。MDD阈值和噪声暴露之间的关联可能不是因果关系，而是由研究中未测量的其他因素介导的。这种关联是一致的，定性，与假设的损失压缩由于外毛细胞功能障碍。皇冠版权所有（c）2021由Elsevier B. V.出版。保留所有权利。
Early signs of noise-induced hearing damage are difficult to identify, as they are often confounded by factors such as age, audiometric thresholds, or even music experience. Much previous research has focused on deficits observed at high intensity levels. In contrast, the present study was designed to test the hypothesis that noise exposure causes a degradation in low-sound-level auditory processing in humans, as a consequence of dysfunction of the inner hair cell pathway. Frequency difference limens (FDLs) and amplitude modulation depth discrimination (MDD) were measured for five center frequencies (0.75, 1, 3, 4 and 6 kHz) at 15 and 25 dB sensation level (SL), as a function of noise exposure, age, audiometric hearing loss, and music experience. Forty participants, aged 33-75 years, with normal hearing up to 1 kHz and mild-to-moderate hearing loss above 2 kHz, were tested. Participants had varying degrees of self reported noise exposure, and varied in music experience. FDL worsened as a function of age. Participants with music experience outperformed the non-experienced in both the FDL and MDD tasks. MDD thresholds were significantly better for high-noise-exposed, than for low-noise-exposed, participants at 25 dB SL, particularly at 6 kHz. No effects of age or hearing loss were observed in the MDD. It is possible that the association between MDD thresholds and noise exposure was not causal, but instead was mediated by other factors that were not measured in the study. The association is consistent, qualitatively, with a hypothesized loss of compression due to outer hair cell dysfunction. Crown Copyright (c) 2021 Published by Elsevier B.V. All rights reserved.