Entrainment of Brain Oscillations by Transcranial Alternating Current Stimulation
Entrainment of Brain Oscillations by Transcranial Alternating Current Stimulation
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DOI：
10.1016/j.cub.2013.12.041
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发表时间：
2014-02-03
期刊：
影响因子：
9.2
通讯作者：
Herrmann, Christoph S.
中科院分区：
文献类型：
--
作者：
Helfrich, Randolph F.;Schneider, Till R.;Herrmann, Christoph S.
神经元夹带的新方法 [1-4] 提供了独特的机会，以特定频率的方式调节感知相关的大脑振荡 [5, 6] 并研究它们对不同认知功能的功能影响。最近，有证据表明 tACS（经颅交流电刺激）可以调节皮质振荡 [7-9]。然而，迄今为止，由于缺乏并发脑电图（EEG）记录，电生理效应的研究受到了阻碍。在这里，我们将 10 Hz tACS 应用于顶枕皮质，并利用同步脑电图记录来研究刺激过程中的神经元夹带。我们开创了一种同步 tACS-EEG 记录的新方法，并成功地将刺激伪影与正在进行的和事件相关的皮层活动分开。我们的结果表明，10 Hz tACS 会增加顶枕叶 α 活动，并使具有与夹带频率相似的固有频率的皮层振荡器同步。此外，我们证明 tACS 以相位依赖的方式调节目标检测性能，突出了 α 振荡对视觉感知的因果作用。
Novel methods for neuronal entrainment [1-4] provide the unique opportunity to modulate perceptually relevant brain oscillations [5, 6] in a frequency-specific manner and to study their functional impact on distinct cognitive functions. Recently, evidence has emerged that tACS (transcranial alternating current stimulation) can modulate cortical oscillations [7-9]. However, the study of electrophysiological effects has been hampered so far by the absence of concurrent electroencephalogram (EEG) recordings. Here, we applied 10 Hz tACS to the parieto-occipital cortex and utilized simultaneous EEG recordings to study neuronal entrainment during stimulation. We pioneer a novel approach for simultaneous tACS-EEG recordings and successfully separate stimulation artifacts from ongoing and event-related cortical activity. Our results reveal that 10 Hz tACS increases parieto-occipital alpha activity and synchronizes cortical oscillators with similar intrinsic frequencies to the entrainment frequency. Additionally, we demonstrate that tACS modulates target detection performance in a phase-dependent fashion highlighting the causal role of alpha oscillations for visual perception.