Immunological Correlates of Prevention of the Onset of Seasonal H3N2 Influenza
Immunological Correlates of Prevention of the Onset of Seasonal H3N2 Influenza
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DOI：
10.1093/infdis/jiac152
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发表时间：
2022-04-27
影响因子：
6.4
通讯作者：
Kawaoka，Yoshihiro
中科院分区：
文献类型：
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作者：
Okuda，Moe;Sakai-Tagawa，Yuko;Kawaoka，Yoshihiro
在流感病毒感染或接种疫苗时，会发生免疫反应，包括产生具有各种功能的抗体，这些抗体有助于保护免受季节性流感病毒感染。在目前的研究中，我们试图通过比较5名亚临床感染者和16名感染季节性H3N2病毒的患者之间不同抗体功能的几种抗体滴度的水平，来确定在预防季节性流感发作中发挥核心作用的抗体功能。对于流感病毒暴露前的抗体滴度，我们发现亚临床感染个体中针对血凝素和神经氨酸酶（NA）蛋白的nAb滴度和酶联免疫吸附试验滴度显著高于患者，而NA抑制滴度和抗体依赖性细胞毒性活性在亚临床感染个体和感染患者之间没有显著差异。这些结果表明，nAb和酶联免疫吸附试验滴度对血凝素和NA作为相关的症状性流感感染。
On influenza virus infection or vaccination, immune responses occur, including the production of antibodies with various functions that contribute to protection from seasonal influenza virus infection. In the current study, we attempted to identify the antibody functions that play a central role in preventing the onset of seasonal influenza by comparing the levels of several antibody titers for different antibody functions between 5 subclinically infected individuals and 16 patients infected with seasonal H3N2 virus. For antibody titers before influenza virus exposure, we found that the nAb titers and enzyme-linked immunosorbent assay titers against hemagglutinin and neuraminidase (NA) proteins in the subclinically infected individuals were significantly higher than those in the patients, whereas the NA inhibition titers and antibody-dependent cellular cytotoxicity activities did not significantly differ between subclinically infected individuals and infected patients. These results suggest that nAb and enzyme-linked immunosorbent assay titers against hemagglutinin and NA serve as correlates of symptomatic influenza infection.