Receptor Usage and Cell Entry of Porcine Epidemic Diarrhea Coronavirus
Receptor Usage and Cell Entry of Porcine Epidemic Diarrhea Coronavirus
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DOI：
10.1128/jvi.00430-15
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发表时间：
2015-06-01
影响因子：
5.4
通讯作者：
Li, Fang
中科院分区：
文献类型：
--
作者：
Liu, Chang;Tang, Jian;Li, Fang
猪流行性腹泻冠状病毒（PEDV）严重损害了美国的猪肉产业。在这里，我们调查受体的使用和PEDV的细胞进入。PEDV识别来自猪和人的蛋白受体氨肽酶N和糖辅助受体N-乙酰神经氨酸。此外，PEDV感染来自猪、人、猴和蝙蝠的细胞。这些结果支持了蝙蝠作为PEDV进化起源的想法，暗示PEDV作为其他物种的潜在威胁，并建议抗病毒策略来控制其传播。
Porcine epidemic diarrhea coronavirus (PEDV) has significantly damaged America's pork industry. Here we investigate the receptor usage and cell entry of PEDV. PEDV recognizes protein receptor aminopeptidase N from pig and human and sugar coreceptor N-acetylneuraminic acid. Moreover, PEDV infects cells from pig, human, monkey, and bat. These results support the idea of bats as an evolutionary origin for PEDV, implicate PEDV as a potential threat to other species, and suggest antiviral strategies to control its spread.