Evaluation of the spontaneously hypertensive rat as a model of attention deficit hyperactivity disorder: acquisition and performance of the DRL-60s test
Evaluation of the spontaneously hypertensive rat as a model of attention deficit hyperactivity disorder: acquisition and performance of the DRL-60s test
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DOI：
10.1016/s0166-4328(99)00156-4
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发表时间：
2000-04-01
影响因子：
2.7
通讯作者：
Jones, DNC
中科院分区：
文献类型：
--
作者：
Bull, E;Reavill, C;Jones, DNC
自发性高血压大鼠（SHR）已被提出作为注意缺陷多动障碍（ADHD）的动物模型。它在各种行为模式中都过于活跃，并且存在持续的注意力缺陷。与Wistar-Kyoto （WKY）大鼠相比，本研究调查了SHR是否会因冲动性增加而表现出对差分低速率（DRL）强化计划的习得和表现受损。并与sd （Sprague-Dawley， CD）大鼠进行性能比较。与WKY或CD大鼠相比，SHR大鼠在该测试中的习得性未受到损害。事实上，WKY大鼠比SHR或CD大鼠花了更长的时间来完成这项任务。与其他品系相比，WKY大鼠在要求高反应率（如FR-1）的训练部分表现较差，但在要求低反应率（如drl -30和drl -60）的训练部分表现较好。在DRL-60s条件下，WKY大鼠的工作效率排序为wri b> SHR b> CD。然而，DRL-60s条件下的反应模式表明WKY大鼠的时间控制能力较差。因此，SHR在DRL测试中的表现似乎并不代表ADHD的有效模型。此外，我们对WKY大鼠的研究结果表明，该菌株对SHR的行为控制较差。(C) 2000 Elsevier Science B.V.版权所有
The spontaneously hypertensive rat (SHR) has been proposed as an animal model of attention deficit hyperactivity disorder (ADHD). It is hyperactive in a variety of behavioural paradigms and has a sustained attention deficit. This study investigated whether the SHR would exhibit impaired acquisition and performance of a differential low rate (DRL) schedule of reinforcement because of increased impulsivity, compared with the Wistar-Kyoto (WKY) rat, its normotensive progenitor. In addition, the performance of both strains was compared with Sprague-Dawley (CD) rats. SHR rats were not impaired in the acquisition of this test compared with WKY or CD rats. Indeed, WKY rats took significantly longer to acquire this task than either SHR or CD rats. The WKY rats performed poorly compared with the other strains in those parts of training that required high response rates (e.g. FR-1), but better where low rates of responding were required (e.g. DRL-30s and DRL-60s). The rank order of efficiency when performance was measured under DRL-60s was WRY > SHR > CD. However, the pattern of responding at DRL-60s suggested poor schedule control for the WKY rats. Therefore, the performance of SHR in the DRL test does not appear to represent a valid model of ADHD. Further, our findings with the WKY rat suggest that this strain is a poor behavioural control for the SHR. (C) 2000 Elsevier Science B.V. All rights reserved.