Voluntary exercise-induced neurogenesis in the postischemic dentate gyrus is associated with spatial memory recovery from stroke
Voluntary exercise-induced neurogenesis in the postischemic dentate gyrus is associated with spatial memory recovery from stroke
复制标题
DOI：
10.1002/jnr.21317
复制
发表时间：
2007-06-01
影响因子：
4.2
通讯作者：
Zhu, Dong Ya
中科院分区：
文献类型：
--
作者：
Luo, Chun Xia;Jiang, Jun;Zhu, Dong Ya
空间认知障碍是中风后常见的损伤。自主运动可以改善受损的空间记忆。齿状回中新产生的神经元对于获得新的海马依赖性记忆是必要的。然而，目前还不清楚中风后的自主运动是否会促进成年人齿状回的神经发生，从而促进空间记忆的恢复。在这里，我们研究了在小鼠局灶性脑缺血自愿或强迫运动对缺血性齿状回和空间记忆的神经发生的影响。暴露于中风后自愿轮运行增强新生儿细胞的存活率和上调磷酸化的cAMP反应元件结合蛋白（CREB）在齿状回和逆转缺血诱导的空间记忆障碍。然而，在暴露于强迫游泳的小鼠中没有观察到新生细胞存活和齿状回中CREB磷酸化的增强以及空间记忆的改善。此外，齿状回中存活的新生细胞总数与小鼠在Morris水迷宫中定位平台的能力之间存在显著相关性。这些结果表明，在成年小鼠中，暴露于自愿运动后缺血性中风可能会促进新生细胞的存活在齿状回上调CREB磷酸化，从而恢复受损的海马依赖性记忆。(c)2007 Wiley-Liss，Inc.
Spatial cognitive impairment is common after stroke insults. Voluntary exercise could improve the impaired spatial memory. Newly generated neurons in the dentate gyrus are necessary for the acquisition of new hippocampus-dependent memories. However, it is not well known whether voluntary exercise after stroke promotes neurogenesis in the adult clentate gyrus, thereby promoting spatial memory recovery. Here, we examined in mice subjected to focal cerebral ischemia the effect of voluntary or forced exercise on neurogenesis in the ischemic clentate gyrus and spatial memory. Exposure to voluntary wheel running after stroke enhanced newborn cell survival and up-regulated the phosphorylation of cAMP response element binding protein (CREB) in the clentate gyrus and reversed ischemia-induced spatial memory impairment. However, the enhanced newborn cell survival and CREB phosphorylation in the clentate gyrus and improved spatial memory were not observed in the mice exposed to forced swimming. Moreover, there was a significant correlation between the total number of surviving newborn cells in the dentate gyrus and the ability of mice to locate the platform in the Morris water maze. These results suggest that, in the adult mice, exposure to voluntary exercise after ischemic stroke may promote newborn cells survival in the dentate gyrus by up-regulating CREB phosphorylation and consequently restore impaired hippocampus-dependent memory. (c) 2007 Wiley-Liss, Inc.