Measurement reproducibility of magnetic resonance imaging-based finite element analysis of proximal femur microarchitecture for in vivo assessment of bone strength.
Measurement reproducibility of magnetic resonance imaging-based finite element analysis of proximal femur microarchitecture for in vivo assessment of bone strength.
复制标题
磁共振成像基于股骨近端微体系结构的有限元分析的测量可重复性，用于体内骨强度评估。
DOI：
10.1007/s10334-014-0475-y
复制
发表时间：
2015-08
期刊：
影响因子：
--
通讯作者：
Rajapakse CS
中科院分区：
文献类型：
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作者：
Chang G;Hotca-Cho A;Rusinek H;Honig S;Mikheev A;Egol K;Regatte RR;Rajapakse CS
骨质疏松症是一种骨骼脆弱的疾病。我们的目标是确定股骨近端强度磁共振评估的测量重现性。这项研究得到了机构审查委员会的批准，并获得了所有受试者的书面知情同意书。我们使用高分辨率 3-D FLASH 序列，在 1 周内以 3T 扫描 12 名受试者 3 次，获得了近端股骨微结构图像。我们应用有限元分析来计算股骨近端刚度和股骨颈弹性模量。日内和日间均方根变异系数和组内相关系数的范围分别为3.5%至6.6%和0.96%至0.98。股骨近端强度磁共振评估的测量重复性适用于与骨质疏松症骨强化干预相关的疾病进展或治疗反应的临床研究。
Osteoporosis is a disease of weak bone. Our goal was to determine the measurement reproducibility of magnetic resonance assessment of proximal femur strength. This study had institutional review board approval, and written informed consent was obtained from all subjects. We obtained images of proximal femur microarchitecture by scanning 12 subjects three times within 1 week at 3T using a high-resolution 3-D FLASH sequence. We applied finite element analysis to compute proximal femur stiffness and femoral neck elastic modulus. Within-day and between-day root-mean-square coefficients of variation and intraclass correlation coefficients ranged from 3.5 to 6.6 % and 0.96 to 0.98, respectively. The measurement reproducibility of magnetic resonance assessment of proximal femur strength is suitable for clinical studies of disease progression or treatment response related to osteoporosis bone-strengthening interventions.