Clinical Significance of Complex Glandular Patterns in Lung Adenocarcinoma: Clinicopathologic and Molecular Study in a Large Series of Cases.
Clinical Significance of Complex Glandular Patterns in Lung Adenocarcinoma: Clinicopathologic and Molecular Study in a Large Series of Cases.
复制标题
DOI：
10.1093/ajcp/aqy032
复制
发表时间：
2018-05-31
影响因子：
3.5
通讯作者：
Sun Y
中科院分区：
文献类型：
--
作者：
Kuang M;Shen X;Yuan C;Hu H;Zhang Y;Pan Y;Cheng C;Zheng D;Cheng L;Zhao Y;Tao X;Li Y;Chen H;Sun Y
探讨复杂腺体模式（CGP）在肺腺癌患者的临床治疗中是否具有潜在作用。我们纳入了 356 名具有可用临床病理信息、基因突变和临床结果的肺腺癌患者进行分析。我们确定了 54 例 (15.2%) CGP 为主的病例。 CGP 与 ALK 重排和 HER2 突变相关。生存分析显示，CGP为主的患者的临床结果比腺泡为主的患者差（总生存期[OS]，66.4 vs 90.3个月，P < .01；无复发生存期[RFS]，50.1 vs 73.1个月，P = 0.022），但与实性为主的亚型肿瘤相当（OS，66.4 vs 67.8）个月，P = .558；RFS，50.1 与 41.3 个月，P = .258）。特别是，筛状腺体和融合腺体模式的共存与最差的生存率相关，死亡风险增加 2.25 倍（风险比，3.25；95% 置信区间，1.35-7.86，P = .009）。我们的结果为 CGP 在临床管理中的潜在作用提供了新的见解，并将有利于肺腺癌患者的治疗决策。
To explore whether complex glandular patterns (CGPs) have a potential role in the clinical management of patients with lung adenocarcinoma. We included 356 patients with lung adenocarcinoma with available clinicopathologic information, gene mutations, and clinical outcomes for analysis. We identified 54 (15.2%) CGP-predominant cases. The CGPs were associated with ALK rearrangement and HER2 mutation. Survival analysis showed that the clinical outcome of CGP-predominant patients was worse than that for acinar-predominant patients (overall survival [OS], 66.4 vs 90.3 months, P < .01; recurrence-free survival [RFS], 50.1 vs 73.1 months, P = .022) but was comparable with solid-predominant subtype tumors (OS, 66.4 vs 67.8 months, P = .558; RFS, 50.1 vs 41.3 months, P = .258). In particular, the coexistence of the cribriform and fused gland pattern was associated with the poorest survival, with a death risk increased by 2.25-fold (hazard ratio, 3.25; 95% confidence interval, 1.35-7.86, P = .009). Our results provide new insight into the potential role of CGPs in clinical management and will be beneficial for treatment decision making in patients with lung adenocarcinoma.
登录
查看更多内容
影响因子：
3.3
作者：
Moreira, Andre L.;Joubert, Philippe;Rekhtman, Natasha
通讯作者：
Rekhtman, Natasha
影响因子：
5.6
作者：
Xu, Lauren;Tavora, Fabio;Burke, Allen
通讯作者：
Burke, Allen
影响因子：
3.6
作者：
Behera, Madhusmita;Owonikoko, Taofeek K.;Sica, Gabriel L.
通讯作者：
Sica, Gabriel L.
DOI：
10.1097/jto.0b013e318206a221
发表时间：
2011-02
期刊：
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
影响因子：
--
作者：
Travis WD;Brambilla E;Noguchi M;Nicholson AG;Geisinger KR;Yatabe Y;Beer DG;Powell CA;Riely GJ;Van Schil PE;Garg K;Austin JH;Asamura H;Rusch VW;Hirsch FR;Scagliotti G;Mitsudomi T;Huber RM;Ishikawa Y;Jett J;Sanchez-Cespedes M;Sculier JP;Takahashi T;Tsuboi M;Vansteenkiste J;Wistuba I;Yang PC;Aberle D;Brambilla C;Flieder D;Franklin W;Gazdar A;Gould M;Hasleton P;Henderson D;Johnson B;Johnson D;Kerr K;Kuriyama K;Lee JS;Miller VA;Petersen I;Roggli V;Rosell R;Saijo N;Thunnissen E;Tsao M;Yankelewitz D
通讯作者：
Yankelewitz D
DOI：
10.1097/pas.0000000000000134
发表时间：
2014-04
期刊：
The American journal of surgical pathology
影响因子：
--
作者：
Kadota K;Villena-Vargas J;Yoshizawa A;Motoi N;Sima CS;Riely GJ;Rusch VW;Adusumilli PS;Travis WD
通讯作者：
Travis WD