THE HOMEODOMAIN LIM PROTEIN ISL-1 IS EXPRESSED IN SUBSETS OF NEURONS AND ENDOCRINE-CELLS IN THE ADULT-RAT
THE HOMEODOMAIN LIM PROTEIN ISL-1 IS EXPRESSED IN SUBSETS OF NEURONS AND ENDOCRINE-CELLS IN THE ADULT-RAT
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DOI：
10.1016/0896-6273(91)90334-v
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发表时间：
1991-12-01
期刊：
影响因子：
16.2
通讯作者：
EDLUND, T
中科院分区：
文献类型：
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作者：
THOR, S;ERICSON, J;EDLUND, T
我们用免疫细胞化学方法定位同源域LIM蛋白Isl-1在成年大鼠。Isl-1免疫反应性在内分泌系统的多肽酶产生细胞、外周神经系统的神经元和脑核的子集中表达。Isl-1也在脊髓和脑干的运动神经元亚群中表达，但不在涉及感觉功能的中枢神经系统区域或新皮层区域中表达。Isl-1的表达模式表明，该基因可能参与这些细胞的分化表型特性的规范和维持。
We have used immunocytochemical methods to localize the homeodomain LIM protein Isl-1 in the adult rat. Isl-1 immunoreactivity is expressed in polypeptide hormone-producing cells of the endocrine system, in neurons of the peripheral nervous system, and in a subset of brain nuclei. Isl-1 is also expressed in a subset of motoneurons in the spinal cord and brain stem, but not in regions of the central nervous system involved in sensory function or in neocortical areas. The pattern of expression of Isl-1 suggests that this gene may be involved in the specification and maintenance of differentiated phenotypical properties of these cells.