Erythropoietin levels in uremic nephric and anephric patients.
Erythropoietin levels in uremic nephric and anephric patients.
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尿毒症肾病和肾病患者的促红细胞生成素水平。
DOI：
10.5555/uri:pii:0022214379900313
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发表时间：
1979
期刊：
影响因子：
--
通讯作者：
A. Erslev
中科院分区：
文献类型：
--
作者：
J. Caro;J. Caro;S. Brown;S. Brown;O. Miller;O. Miller;T. Murray;T. Murray;A. Erslev;A. Erslev
采用血浆浓缩法测定了慢性血液透析患者肾性贫血和肾性贫血患者的红细胞生成素滴度。在被研究的11名无肾患者中，有8名患者的红细胞生成素水平下降，但可检测到促红细胞生成素的水平，这表明肾外促红细胞生成素在无肾患者的红细胞生成调节中发挥作用。在14例肾性尿毒症患者中，促红细胞生成素的产生变化更大，其中一组8例患者的促红细胞生成素水平在正常非贫血患者的范围内(3.9-15 mU/ml)，另一组6例患者的促红细胞生成素水平高于正常(>15 mU/ml)。研究发现，两组患者的贫血程度相同，表明第二组患者的骨髓对促红细胞生成素的反应较弱。继发性甲状旁腺功能亢进症的严重程度在第二组中被发现较高，提示甲状旁腺素在骨髓无反应中起作用。正常人和尿毒症肾病、无肾患者血浆中促红细胞生成素的生物学活性和免疫学活性之间有很好的相关性。
Erythropoietin titers were measured in anemic nephric and anephric patients undergoing chronic hemodialysis by utilizing a plasma concentration technique. In eight out of 11 anephric patients studied, decreased but detectable levels of erythropoietin were found, suggesting that extrarenal erythropoietin plays a role in the regulation of red cell production in anephric patients. In 14 nephric uremic patients, erythropoietin production was found to be more variable, with one group of eight patients having erythropoietin levels in the range for normal nonanemic individuals (3.9 to 15 mU/ml), and a second group of six patients with erythropoietin higher than normal (greater than 15 mU/ml). Both groups were found to be equally anemic, indicating that in the second group the bone marrow is less responsive to erythropoietin. The severity of secondary hyperparathyroidism was found to be higher in this second group, suggesting a role of PTH in the bone marrow unresponsiveness. A good correlation between biological and immunological erythropoietin activities was found in the plasma from normal subjects and uremic nephric and anephric patients.