Accessibility and Quality of Online Cancer-Related Clinical Trial Information for Naïve Searchers.
Accessibility and Quality of Online Cancer-Related Clinical Trial Information for Naïve Searchers.
复制标题
为新手搜索者提供在线癌症相关临床试验信息的可访问性和质量。
DOI：
10.1158/1055-9965.epi-15-0274
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发表时间：
2015
期刊：
影响因子：
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通讯作者：
Gray,StacyW
中科院分区：
文献类型：
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作者：
Abel,GregoryA;Cronin,AngelM;Earles,Kristofer;Gray,StacyW
尽管互联网可能有助于提高癌症患者对临床试验的认识，但人们对在线临床试验信息的可及性和质量知之甚少。我们模拟了一位没有临床试验知识的naïve癌症患者的经历，通过搜索三个流行的搜索引擎搜索乳腺癌、肺癌、前列腺癌和骨髓增生异常综合征（MDS）的治疗信息。两名编码员独立评估网站内容的可访问性和质量。我们筛选了120个网站，并确定了40个独特的网站进行分析。总体而言，85%[95%置信区间（CI）， 70%-94%]的网站在登陆页面上提到临床试验，68%（51%-81%）的网站包含特定试验的链接。整体可读性很差。大约一半的网站（36%-68%）包含关于临床试验的潜在益处和风险的信息，40%的网站提供关于何时更新的信息（25%-57%）。在有特定临床试验链接的网站中，只有44%（25%-65%）提供了允许患者自定义搜索结果的交互界面；乳腺（100%）和前列腺（50%）部位的相互作用大于肺（25%）和MDS （14%；P= 0.007）。虽然癌症临床试验信息可以在互联网上广泛获取，但其质量参差不齐。鉴于许多新兴的癌症治疗方法都是基于疾病或基因组特征进行个性化的，基于网络的交互式界面可以作为强大的工具，帮助患者找到合适的临床试验。如果不加强努力确保癌症治疗网站的互动性，患者对相关临床试验的认识可能仍然很低。癌症流行病学生物标志物；24 (10);1629 - 31所示。AACR©2015。
Although the Internet may help to increase cancer patients' awareness of clinical trials, little is known about the accessibility and quality of online clinical trial information. We simulated the experience of a naïve cancer patient without clinical trial knowledge by searching three popular search engines for treatment information for breast, lung, and prostate cancer, and myelodysplastic syndromes (MDS). Two coders independently evaluated website content for accessibility and quality. We screened 120 websites and identified 40 unique sites for analysis. Overall, 85% [95% confidence interval (CI), 70%–94%] of sites mentioned clinical trials on the landing page and 68% (51%–81%) included links to specific trials. Overall readability was poor. Approximately half of websites (36%–68%) included information on the potential benefits and risks of clinical trials and 40% provided information about when the site had been updated (25%–57%). Among sites with links to specific clinical trials, only 44% (25%–65%) provided an interactive interface that would allow patients to customize search results; breast (100%) and prostate (50%) sites were more interactive than lung (25%) and MDS (14%;P= 0.007). Although cancer clinical trial information is widely available on the Internet, its quality is highly variable. Given the fact that many emerging cancer therapeutics are personalized based on disease or genomic characteristics, interactive web-based interfaces could serve as powerful vehicles to help patients locate appropriate clinical trials. Without enhanced efforts to ensure greater interactivity of cancer treatment websites, patient awareness of relevant clinical trials may remain low.Cancer Epidemiol Biomarkers Prev; 24(10); 1629–31. ©2015 AACR.