Fabrication of silver-doped apatite powders from silver-substituted octacalcium phosphate powders via solid?solid phase-conversion process
Fabrication of silver-doped apatite powders from silver-substituted octacalcium phosphate powders via solid?solid phase-conversion process
复制标题
银取代磷酸八钙粉末固相转化法制备银掺杂磷灰石粉末
DOI：
10.1016/j.ceramint.2021.05.287
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发表时间：
2021
影响因子：
5.2
通讯作者：
Horie Masanori
中科院分区：
文献类型：
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作者：
Sugiura Yuki;Horie Masanori
磷灰石（羟基磷灰石，HAp;碳酸磷灰石，CO 3Ap）材料的优良生物相容性使其成为骨替代材料的合适候选者。但是，它们没有抗菌能力。同时，银（Ag）在广泛的抗菌谱中表现出优异的抗菌性能。然而，可溶性银盐表现出细胞毒性和不良的美学特性。我们将Ag掺杂到磷灰石单元晶格中，以使复合材料表现出抗菌接触能力，同时限制Ag+的释放，这是不需要的颜色变化和细胞毒性的主要原因。当将磷酸八钙（OCP）（Ag-OCP）中的Ca被银离子取代的晶体结构浸渍在水和/或含（NH 4）2CO 3的溶液中时，Ag-OCP通过固-固相转化过程转化为含Ag的磷灰石。磷灰石和前体Ag-OCP的Ag含量相同。磷灰石样品的CO 3含量取决于处理溶液中（NH 4）2CO 3的浓度。一锅，单步处理能够合成含银HAp和CO 3Ap。此外，这些含Ag的HAp和CO 3Ap样品显示出与前体Ag-OCP相比几乎没有颜色变化。
The excellent biocompatibility of apatite (hydroxyapatite, HAp; carbonate apatite, CO3Ap) materials makes them suitable candidates as bone substitutes. However, they have no antibacterial ability. Meanwhile, silver (Ag) exhibits excellent antibacterial properties across a wide antibacterial spectrum. However, soluble Ag salts exhibit cytotoxicity and poor aesthetic properties. We dope Ag into an apatite unit lattice in order for the composite material to exhibit antibacterial contact abilities while simultaneously limiting the release of Ag+, which is the primary cause of the unwanted color changes and cytotoxicity. When a crystal structure in which silver ions are substituted for Ca in octacalcium phosphate (OCP) (Ag-OCP) is immersed in water and/or (NH4)2CO3-containing solutions, Ag-OCP is converted into an apatite containing Ag via a solid–solid phase-transformation process. The Ag contents of the apatite and precursor Ag-OCP are the same. The CO3content of apatite samples depends on the (NH4)2CO3concentration of the treated solutions. A single-pot, single-step treatment enables the synthesis of both Ag-containing HAp and CO3Ap. Further, these Ag-containing HAp and CO3Ap samples show little color change from that of the precursor Ag-OCP.